Difference between revisions of "SplB"
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− | * '''Structure:''' http://www.rcsb.org/pdb/explore/explore.do?structureId=4FHC 4FHC (SplB from ''Geobacillus thermodenitrificans'', 72% identity, 90% similarity) {{PubMed|22761404}} | + | * '''Structure:''' [http://www.rcsb.org/pdb/explore/explore.do?structureId=4FHC 4FHC] (SplB from ''Geobacillus thermodenitrificans'', 72% identity, 90% similarity) {{PubMed|22761404}} |
* '''UniProt:''' [http://www.uniprot.org/uniprot/P37956 P37956] | * '''UniProt:''' [http://www.uniprot.org/uniprot/P37956 P37956] |
Revision as of 14:32, 15 August 2013
- Description: spore photoproduct lyase
Gene name | splB |
Synonyms | spl |
Essential | no |
Product | spore photoproduct lyase |
Function | protection of spore DNA against photodamage |
Gene expression levels in SubtiExpress: splB | |
MW, pI | 39 kDa, 8.524 |
Gene length, protein length | 1026 bp, 342 aa |
Immediate neighbours | splA, ykwB |
Sequences | Protein DNA DNA_with_flanks |
Genetic context This image was kindly provided by SubtiList
| |
Expression at a glance PubMed |
Contents
Categories containing this gene/protein
DNA repair/ recombination, sporulation proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU13930
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- repairs a special thymine dimer (5-thyminyl-5,6-dihydrothymine), which is commonly called spore photoproduct at the early germination phase
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- contains a [4Fe-4S] cluster, uses the [4Fe-4S] cluster to reduce SAM
- Effectors of protein activity:
Database entries
- UniProt: P37956
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Additional information:
Biological materials
- Mutant: BP130 (del splB::spc), available in Fabian Commichau's lab
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Alhosna Benjdia
DNA photolyases and SP lyase: structure and mechanism of light-dependent and independent DNA lyases.
Curr Opin Struct Biol: 2012, 22(6);711-20
[PubMed:23164663]
[WorldCat.org]
[DOI]
(I p)
Original publications