Difference between revisions of "Metabolism of signalling nucleotides"

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(Important original publications)
(Genes in this functional category)
Line 32: Line 32:
  
 
===c-di-GMP degradation (presence of an EAL domain)===
 
===c-di-GMP degradation (presence of an EAL domain)===
* [[YkoW]]
+
* [[DgcW]]
 
* [[YkuI]]
 
* [[YkuI]]
* [[YuxH]]
+
* [[PdeH]]
  
 
=== c-di-GMP synthesis/ based on similarity (presence of a GGDEF domain)===
 
=== c-di-GMP synthesis/ based on similarity (presence of a GGDEF domain)===
 
* [[GdpP]]
 
* [[GdpP]]
 
* [[YdaK]]
 
* [[YdaK]]
* [[YhcK]]
+
* [[DgcK]]
* [[YkoW]]
+
* [[DgcW]]
* [[YtrP]] (this enzyme may be inactive due to the lack of important residues)
+
* [[DgcP]] (this enzyme lacks important residues)
  
 
=== Targets of signalling nucleotides ===
 
=== Targets of signalling nucleotides ===
Line 52: Line 52:
  
 
* c-di-GMP targets
 
* c-di-GMP targets
** [[YpfA]] (contains a PilZ domain)
+
** [[DgrA]] (contains a PilZ domain)
  
 
* potential c-di-AMP targets
 
* potential c-di-AMP targets
** [[KtrA]] (binds c-di-AMP ''in vivo'') {{PubMed|23671116}}  
+
** [[KtrA]] (binds c-di-AMP ''in vivo'') {{PubMed|23671116}}
  
 
==Important original publications==
 
==Important original publications==

Revision as of 10:33, 10 August 2013

Parent categories
Neighbouring categories
Related categories

none

Genes in this functional category

ppGpp synthesis and degradation

c-di-AMP synthesis

Control of c-di-AMP synthesis

Note that c-di-AMP is essential for the growth of B. subtilis, but accumulation of the nucleotide is detrimental as well PubMed

c-di-AMP degradation

c-di-GMP degradation (presence of an EAL domain)

c-di-GMP synthesis/ based on similarity (presence of a GGDEF domain)

Targets of signalling nucleotides

  • c-di-GMP targets
    • DgrA (contains a PilZ domain)
  • potential c-di-AMP targets

Important original publications


Important reviews

Rebecca M Corrigan, Angelika Gründling
Cyclic di-AMP: another second messenger enters the fray.
Nat Rev Microbiol: 2013, 11(8);513-24
[PubMed:23812326] [WorldCat.org] [DOI] (I p)

Dimpy Kalia, Gökçe Merey, Shizuka Nakayama, Yue Zheng, Jie Zhou, Yiling Luo, Min Guo, Benjamin T Roembke, Herman O Sintim
Nucleotide, c-di-GMP, c-di-AMP, cGMP, cAMP, (p)ppGpp signaling in bacteria and implications in pathogenesis.
Chem Soc Rev: 2013, 42(1);305-41
[PubMed:23023210] [WorldCat.org] [DOI] (I p)

Mark Gomelsky
cAMP, c-di-GMP, c-di-AMP and now cGMP: bacteria use them all!
Mol Microbiol: 2011, 79(3);562-5
[PubMed:21255104] [WorldCat.org] [DOI] (I p)

Tilman Schirmer, Urs Jenal
Structural and mechanistic determinants of c-di-GMP signalling.
Nat Rev Microbiol: 2009, 7(10);724-35
[PubMed:19756011] [WorldCat.org] [DOI] (I p)

Regine Hengge
Principles of c-di-GMP signalling in bacteria.
Nat Rev Microbiol: 2009, 7(4);263-73
[PubMed:19287449] [WorldCat.org] [DOI] (I p)

Ute Römling
Great times for small molecules: c-di-AMP, a second messenger candidate in Bacteria and Archaea.
Sci Signal: 2008, 1(33);pe39
[PubMed:18714086] [WorldCat.org] [DOI] (I e)

Peggy A Cotter, Scott Stibitz
c-di-GMP-mediated regulation of virulence and biofilm formation.
Curr Opin Microbiol: 2007, 10(1);17-23
[PubMed:17208514] [WorldCat.org] [DOI] (P p)

Ute Römling, Mark Gomelsky, Michael Y Galperin
C-di-GMP: the dawning of a novel bacterial signalling system.
Mol Microbiol: 2005, 57(3);629-39
[PubMed:16045609] [WorldCat.org] [DOI] (P p)


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