Difference between revisions of "MdtR"

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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yusN]]'', ''[[mdtP]]''
 
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yusN]]'', ''[[mdtP]]''
 
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU32870 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU32870 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU32870 Advanced_DNA]
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU32870 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU32870 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU32870 DNA_with_flanks]
 
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|colspan="2" | '''Genetic context''' <br/> [[Image:yusO_context.gif]]
 
|colspan="2" | '''Genetic context''' <br/> [[Image:yusO_context.gif]]

Revision as of 11:13, 14 May 2013

  • Description: transcription repressor of the multidrug-resistance mdtR-mdtP operon

Gene name mdtR
Synonyms yusO
Essential no
Product transcription repressor (MarR family)
Function regulation of the multidrug-resistance mdtR-mdtP operon
Gene expression levels in SubtiExpress: mdtR
MW, pI 17 kDa, 6.376
Gene length, protein length 465 bp, 155 aa
Immediate neighbours yusN, mdtP
Sequences Protein DNA DNA_with_flanks
Genetic context
YusO context.gif



Categories containing this gene/protein

transcription factors and their control, resistance against toxins/ antibiotics

This gene is a member of the following regulons

MdtR regulon

The MdtR regulon:

The gene

Basic information

  • Locus tag:

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism: repression by MdtR PubMed
  • Additional information:

Biological materials

  • Mutant: GP1115 (spc), available in Stülke lab
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Ji-Yun Kim, Takashi Inaoka, Kazutaka Hirooka, Hiroshi Matsuoka, Makiko Murata, Reiko Ohki, Yoshikazu Adachi, Yasutaro Fujita, Kozo Ochi
Identification and characterization of a novel multidrug resistance operon, mdtRP (yusOP), of Bacillus subtilis.
J Bacteriol: 2009, 191(10);3273-81
[PubMed:19286808] [WorldCat.org] [DOI] (I p)