Difference between revisions of "BdbA"

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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[sunS]]'', ''[[sunT]]''
 
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[sunS]]'', ''[[sunT]]''
 
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU21460 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU21460 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU21460 Advanced_DNA]
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU21460 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU21460 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU21460 DNA_with_flanks]
 
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|colspan="2" | '''Genetic context''' <br/> [[Image:bdbA_context.gif]]
 
|colspan="2" | '''Genetic context''' <br/> [[Image:bdbA_context.gif]]

Revision as of 10:30, 14 May 2013

  • Description: thiol-disulfide oxidoreductase

Gene name bdbA
Synonyms yolI
Essential no
Product thiol-disulfide oxidoreductase
Function oxidative folding of proteins
Gene expression levels in SubtiExpress: bdbA
Metabolic function and regulation of this protein in SubtiPathways:
Protein secretion
MW, pI 16 kDa, 8.337
Gene length, protein length 411 bp, 137 aa
Immediate neighbours sunS, sunT
Sequences Protein DNA DNA_with_flanks
Genetic context
BdbA context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
BdbA expression.png
























Categories containing this gene/protein

chaperones/ protein folding, SP-beta prophage

This gene is a member of the following regulons

Abh regulon, AbrB regulon Rok regulon, YvrHb regulon

The gene

Basic information

  • Locus tag: BSU21460

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: thioredoxin family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Sigma factor:
  • Additional information:
    • the amount of the mRNA is substantially decreased upon depletion of RNase Y PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Additional publications: PubMed

Lehnik-Habrink M, Schaffer M, Mäder U, Diethmaier C, Herzberg C, Stülke J  
RNA processing in Bacillus subtilis: identification of targets of the essential RNase Y. 
Mol Microbiol. 2011 81(6): 1459-1473. 
PubMed:21815947

Mark Albano, Wiep Klaas Smits, Linh T Y Ho, Barbara Kraigher, Ines Mandic-Mulec, Oscar P Kuipers, David Dubnau
The Rok protein of Bacillus subtilis represses genes for cell surface and extracellular functions.
J Bacteriol: 2005, 187(6);2010-9
[PubMed:15743949] [WorldCat.org] [DOI] (P p)

Ronald Dorenbos, Torsten Stein, Jorrit Kabel, Claude Bruand, Albert Bolhuis, Sierd Bron, Wim J Quax, Jan Maarten Van Dijl
Thiol-disulfide oxidoreductases are essential for the production of the lantibiotic sublancin 168.
J Biol Chem: 2002, 277(19);16682-8
[PubMed:11872755] [WorldCat.org] [DOI] (P p)