Difference between revisions of "AlbA"

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|style="background:#ABCDEF;" align="center"|'''Function''' || antilisterial bacteriocin (subtilosin) production
 
|style="background:#ABCDEF;" align="center"|'''Function''' || antilisterial bacteriocin (subtilosin) production
 
|-
 
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU37370 albA]
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU37370 albA]
 
|-
 
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 51 kDa, 6.195   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 51 kDa, 6.195   
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[sboX]]'', ''[[albB]]''
 
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[sboX]]'', ''[[albB]]''
 
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|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+&#91;EMBLCDS:CAB15764&#93;+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU37370 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU37370 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU37370 Advanced_DNA]
 
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|colspan="2" | '''Genetic context''' <br/> [[Image:albA_context.gif]]
 
|colspan="2" | '''Genetic context''' <br/> [[Image:albA_context.gif]]

Revision as of 14:07, 13 May 2013

  • Description: radical S-adenosylmethionine enzyme, antilisterial bacteriocin (subtilosin) production

Gene name albA
Synonyms ywiA
Essential no
Product radical S-adenosylmethionine enzyme
Function antilisterial bacteriocin (subtilosin) production
Gene expression levels in SubtiExpress: albA
MW, pI 51 kDa, 6.195
Gene length, protein length 1344 bp, 448 aa
Immediate neighbours sboX, albB
Sequences Protein DNA Advanced_DNA
Genetic context
AlbA context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
AlbA expression.png
























Categories containing this gene/protein

miscellaneous metabolic pathways, biosynthesis of antibacterial compounds

This gene is a member of the following regulons

AbrB regulon, ResD regulon, Rok regulon

The gene

Basic information

  • Locus tag: BSU37370

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
    • catalyzes thioether bond formation in subtilosin A PubMed
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s): contains two [4Fe-4S] clusters PubMed
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Additional publications: PubMed

Mark A Strauch, Benjamin G Bobay, John Cavanagh, Fude Yao, Angelo Wilson, Yoann Le Breton
Abh and AbrB control of Bacillus subtilis antimicrobial gene expression.
J Bacteriol: 2007, 189(21);7720-32
[PubMed:17720793] [WorldCat.org] [DOI] (P p)

Paul D Straight, Michael A Fischbach, Christopher T Walsh, David Z Rudner, Roberto Kolter
A singular enzymatic megacomplex from Bacillus subtilis.
Proc Natl Acad Sci U S A: 2007, 104(1);305-10
[PubMed:17190806] [WorldCat.org] [DOI] (P p)

Mark Albano, Wiep Klaas Smits, Linh T Y Ho, Barbara Kraigher, Ines Mandic-Mulec, Oscar P Kuipers, David Dubnau
The Rok protein of Bacillus subtilis represses genes for cell surface and extracellular functions.
J Bacteriol: 2005, 187(6);2010-9
[PubMed:15743949] [WorldCat.org] [DOI] (P p)

M M Nakano, G Zheng, P Zuber
Dual control of sbo-alb operon expression by the Spo0 and ResDE systems of signal transduction under anaerobic conditions in Bacillus subtilis.
J Bacteriol: 2000, 182(11);3274-7
[PubMed:10809710] [WorldCat.org] [DOI] (P p)

G Zheng, R Hehn, P Zuber
Mutational analysis of the sbo-alb locus of Bacillus subtilis: identification of genes required for subtilosin production and immunity.
J Bacteriol: 2000, 182(11);3266-73
[PubMed:10809709] [WorldCat.org] [DOI] (P p)

G Zheng, L Z Yan, J C Vederas, P Zuber
Genes of the sbo-alb locus of Bacillus subtilis are required for production of the antilisterial bacteriocin subtilosin.
J Bacteriol: 1999, 181(23);7346-55
[PubMed:10572140] [WorldCat.org] [DOI] (P p)