Difference between revisions of "RsiW"

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|style="background:#ABCDEF;" align="center"|'''Function''' || control of [[SigW]] activity
 
|style="background:#ABCDEF;" align="center"|'''Function''' || control of [[SigW]] activity
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU01740 rsiW]
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU01740 rsiW]
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/RsiW RsiW]
 
|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/RsiW RsiW]
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[sigW]]'', ''[[cdaA]]''
 
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[sigW]]'', ''[[cdaA]]''
 
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|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+&#91;EMBLCDS:CAB11950&#93;+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU01740 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU01740 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU01740 Advanced_DNA]
 
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Revision as of 12:00, 13 May 2013

  • Description: anti-SigW

Gene name rsiW
Synonyms ybbM
Essential no
Product anti-SigW
Function control of SigW activity
Gene expression levels in SubtiExpress: rsiW
Interactions involving this protein in SubtInteract: RsiW
MW, pI 23 kDa, 6.646
Gene length, protein length 624 bp, 208 aa
Immediate neighbours sigW, cdaA
Sequences Protein DNA Advanced_DNA
Genetic context
YbbM context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
RsiW expression.png















Categories containing this gene/protein

sigma factors and their control, cell envelope stress proteins (controlled by SigM, V, W, X, Y), membrane proteins

This gene is a member of the following regulons

AbrB regulon, SigW regulon

The gene

Basic information

  • Locus tag: BSU01740

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: anti-sigma-W factor family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity: degraded by RasP and PrsW under conditions of alkali shock or in the presence of antimicrobial peptides, respectively. This results in the release of SigW

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • induced under conditions of alkali shock or in the presence of the toxin SdpC (SigW) PubMed
    • repressed during logrithmic growth (AbrB) PubMed
  • Regulatory mechanism:
  • Additional information: the mRNA is very stable (half-life > 15 min) PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Thomas Wiegert, University of Bayreuth, Germany Homepage

Your additional remarks

References

Reviews

Additional reviews: PubMed

Gu Chen, Xu Zhang
New insights into S2P signaling cascades: regulation, variation, and conservation.
Protein Sci: 2010, 19(11);2015-30
[PubMed:20836086] [WorldCat.org] [DOI] (I p)

Original Publications