SivA

• Description: inhibitor of KinA autophosphorylation, and subsequently of entry into sporulation
  
  

Gene name	yweA
Synonyms	ipa-74d
Essential	no
Product	inhibitor of KinA autophosphorylation
Function	control of entry into sporulation via the phosphorelay
Gene expression levels in SubtiExpress: yweA
MW, pI	16 kDa, 7.175
Gene length, protein length	462 bp, 154 aa
Immediate neighbours	rocG, spsL
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

phosphorelay

This gene is a member of the following regulons

AbrB regulon

The gene

Basic information

• Locus tag: BSU37800

Phenotypes of a mutant

• the sivA bslA double mutant exhibits a more severe loss of repellency of the biofilm surface as compared to the bslA mutant PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:
  • inhibits KinA autophophorylation PubMed

• Protein family:

• Paralogous protein(s): BslA

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • membrane (according to Swiss-Prot)
  • extracellular (signal peptide) PubMed

Database entries

• Structure:

• UniProt: P39632

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: sivA PubMed

• Expression browser: yweA PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:
  • AbrB: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Additional publications: PubMed