Difference between revisions of "LiaS"
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| − | * '''Description:''' [[two-component systems|two-component]] sensor kinase, response to bacitracin <br/><br/> | + | * '''Description:''' [[two-component systems|two-component]] sensor kinase/phosphatase, response to bacitracin <br/><br/> |
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=== Additional information=== | === Additional information=== | ||
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=== Basic information/ Evolution === | === Basic information/ Evolution === | ||
| − | * '''Catalyzed reaction/ biological activity:''' autophosphorylation, phosphorylation of [[LiaR]] | + | * '''Catalyzed reaction/ biological activity:''' |
| + | ** autophosphorylation, phosphorylation of [[LiaR]] | ||
| + | ** dephosphorylation of [[LiaR]] in the absence of the stress signal {{PubMed|23279150}} | ||
* '''Protein family:''' | * '''Protein family:''' | ||
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* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
| + | ** LiaS kinase activity is inhibited by [[LiaF]], phosphatase acitivity is maintained by [[LiaF]] in the absence of the stress signal {{PubMed|23279150}} | ||
* '''[[SubtInteract|Interactions]]:''' | * '''[[SubtInteract|Interactions]]:''' | ||
| Line 152: | Line 153: | ||
=References= | =References= | ||
'''Additional publications:''' {{PubMed|22964256,22092710}} | '''Additional publications:''' {{PubMed|22964256,22092710}} | ||
| − | <pubmed>18394148,19164152,15273097,17921301,10094672,19164157,14651641,17600057,17660417,16816187,15101989,17660417,20057163 </pubmed> | + | <pubmed>18394148,19164152,15273097,17921301,10094672,19164157,14651641,17600057,17660417,16816187,15101989,17660417,20057163 23279150</pubmed> |
[[Category:Protein-coding genes]], [[Category:two-component systems]] | [[Category:Protein-coding genes]], [[Category:two-component systems]] | ||
Revision as of 10:31, 3 January 2013
- Description: two-component sensor kinase/phosphatase, response to bacitracin
| Gene name | liaS |
| Synonyms | yvqE |
| Essential | no |
| Product | two-component sensor kinase |
| Function | control of LiaR activity in response to bacitracin |
| Gene expression levels in SubtiExpress: liaS | |
| Interactions involving this protein in SubtInteract: LiaS | |
| MW, pI | 40 kDa, 7.333 |
| Gene length, protein length | 1080 bp, 360 aa |
| Immediate neighbours | liaR, liaF |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Expression at a glance PubMed
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Contents
Categories containing this gene/protein
protein modification, transcription factors and their control, resistance against oxidative and electrophile stress, resistance against toxins/ antibiotics, membrane proteins, phosphoproteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU33090
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains: two transmembrane segments, C-terminal histidine phosphotransferase domain
- Modification: autophosphorylation on a His residue
- Cofactor(s):
- Effectors of protein activity:
- Localization: cell membrane (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: O32198
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
John Helmann, Cornell University, USA Homepage
Your additional remarks
References
Additional publications: PubMed ,
