SpoIIIE

• Description: ATP-dependent DNA translocase, transports the forespore chromosome across the sporulation septum
  
  

Gene name	spoIIIE
Synonyms
Essential	no
Product	ATP-dependent DNA translocase required for chromosome partitioning through the septum into the forespore
Function	chromosome partition during sporulation
Gene expression levels in SubtiExpress: spoIIIE
MW, pI	86 kDa, 6.757
Gene length, protein length	2361 bp, 787 aa
Immediate neighbours	ylzJ, ymfC
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

DNA condensation/ segregation, sporulation/ other, membrane proteins

The gene

Basic information

• Locus tag: BSU16800

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:
  • transports the forespore chromosome across the sporulation septum PubMed
  • translocates septum-entrapped DNA only when septum closure precedes complete segregation of chromosomes PubMed
  • the two DNA translocases SftA and SpoIIIE synergistically affect chromosome dimer resolution presumably by positioning the dif sites in close proximity, before or after completion of cell division, respectively PubMed

• Protein family:

• Paralogous protein(s): SftA

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: transmembrane domain mediates dynamic localization to active division sites PubMed

Database entries

• Structure:

• UniProt: P21458

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: spoIIIE PubMed

• Expression browser: spoIIIE PubMed

• Sigma factor: SigA PubMed

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: