Difference between revisions of "YcnK"
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| − | * '''Description:''' transcription repressor of the ''[[ycnK]]-[[ycnJ]]-[[ycnI]]'' operon <br/><br/> | + | * '''Description:''' copper-responsive transcription repressor of the ''[[ycnK]]-[[ycnJ]]-[[ycnI]]'' operon <br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
| Line 10: | Line 10: | ||
|style="background:#ABCDEF;" align="center"| '''Essential''' || no | |style="background:#ABCDEF;" align="center"| '''Essential''' || no | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"| '''Product''' || transcription repressor | + | |style="background:#ABCDEF;" align="center"| '''Product''' || transcription repressor, [[DeoR family]] |
|- | |- | ||
|style="background:#ABCDEF;" align="center"|'''Function''' || regulation of copper uptake | |style="background:#ABCDEF;" align="center"|'''Function''' || regulation of copper uptake | ||
| Line 42: | Line 42: | ||
= This gene is a member of the following [[regulons]] = | = This gene is a member of the following [[regulons]] = | ||
| − | {{SubtiWiki regulon|[[AbrB regulon]]}} | + | {{SubtiWiki regulon|[[AbrB regulon]]}}, |
| + | {{SubtiWiki regulon|[[YcnK regulon]]}} | ||
| + | |||
=The [[YcnK regulon]]:= | =The [[YcnK regulon]]:= | ||
* ''[[ycnK]]-[[ycnJ]]-[[ycnI]]'' | * ''[[ycnK]]-[[ycnJ]]-[[ycnI]]'' | ||
| + | |||
=The gene= | =The gene= | ||
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===Phenotypes of a mutant === | ===Phenotypes of a mutant === | ||
| − | + | * elevated expression of ''[[ycnJ]]'' under conditions of copper excess [http://www.ncbi.nlm.nih.gov/sites/entrez/19168619 PubMed] | |
| − | elevated expression of ''[[ycnJ]]'' under conditions of copper excess [http://www.ncbi.nlm.nih.gov/sites/entrez/19168619 PubMed] | ||
=== Database entries === | === Database entries === | ||
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=== Basic information/ Evolution === | === Basic information/ Evolution === | ||
| − | * '''Catalyzed reaction/ biological activity:''' repression of ''[[ycnJ]]'' expression | + | * '''Catalyzed reaction/ biological activity:''' repression of ''[[ycnK]]-[[ycnJ]]-[[ycnI]]'' expression in the presence of excess copper {{PubMed|22904286,19168619}} |
* '''Protein family:''' DeoR family of transcription factors | * '''Protein family:''' DeoR family of transcription factors | ||
| Line 87: | Line 89: | ||
* '''[[SubtInteract|Interactions]]:''' | * '''[[SubtInteract|Interactions]]:''' | ||
| + | ** forms dimers {{PubMed|22904286}} | ||
* '''[[Localization]]:''' | * '''[[Localization]]:''' | ||
| Line 108: | Line 111: | ||
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ycnK_448461_449033_-1 ycnK] {{PubMed|22383849}} | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ycnK_448461_449033_-1 ycnK] {{PubMed|22383849}} | ||
| − | * '''Sigma factor:''' | + | * '''Sigma factor:''' [[SigA]] {{PubMed|22904286}} |
* '''Regulation:''' | * '''Regulation:''' | ||
** repressed during logrithmic growth ([[AbrB]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/15101989 PubMed] | ** repressed during logrithmic growth ([[AbrB]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/15101989 PubMed] | ||
| + | ** induced by copper limitation ([[YcnK]]) {{PubMed|22904286}} | ||
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
** [[AbrB]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/15101989 PubMed] | ** [[AbrB]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/15101989 PubMed] | ||
| + | ** [[YcnK]]: transcription repression {{PubMed|22904286}} | ||
* '''Additional information:''' | * '''Additional information:''' | ||
Revision as of 08:14, 23 August 2012
| Gene name | ycnK |
| Synonyms | |
| Essential | no |
| Product | transcription repressor, DeoR family |
| Function | regulation of copper uptake |
| Gene expression levels in SubtiExpress: ycnK | |
| MW, pI | 21 kDa, 7.371 |
| Gene length, protein length | 570 bp, 190 aa |
| Immediate neighbours | ycnJ, ycnL |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
trace metal homeostasis (Cu, Zn, Ni, Mn, Mo), transcription factors and their control
This gene is a member of the following regulons
The YcnK regulon:
The gene
Basic information
- Locus tag: BSU03960
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: repression of ycnK-ycnJ-ycnI expression in the presence of excess copper PubMed
- Protein family: DeoR family of transcription factors
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s): copper acts as corepressor PubMed
- Effectors of protein activity:
- Interactions:
- forms dimers PubMed
Database entries
- Structure:
- UniProt: P94433
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Mohamed Marahiel, Marburg University, Germany homepage
Your additional remarks
References
