Difference between revisions of "MutL"

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* '''Effectors of protein activity:'''
 
* '''Effectors of protein activity:'''
  
* '''Interactions:''' [[MutL]] (C-terminal domain)-[[DnaN]] {{PubMed|21050827}}
+
* '''[[SubtInteract|Interactions]]:'''
 +
** [[MutL]] (C-terminal domain)-[[DnaN]] {{PubMed|21050827}}
 +
** [[DnaE]]-[[MutL]]  {{PubMed|21958350}}
  
* '''Localization:'''
+
* '''[[Localization]]:'''
 +
** forms foci at midcell position, the frequency of foci increases upon mismatch formation {{PubMed|21958350}}
  
 
=== Database entries ===
 
=== Database entries ===
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=References=
 
=References=
'''Additional publications:''' {{PubMed|21050827}}
+
'''Additional publications:''' {{PubMed|21050827,21958350}}
 
<pubmed>8760914, 15375129, 20603082 20525796</pubmed>
 
<pubmed>8760914, 15375129, 20603082 20525796</pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 12:08, 24 October 2011

  • Description: DNA mismatch repair

Gene name mutL
Synonyms
Essential no
Product DNA mismatch repair
Function DNA repair
MW, pI 70 kDa, 5.583
Gene length, protein length 1881 bp, 627 aa
Immediate neighbours mutS, ymzD
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
MutL context.gif
This image was kindly provided by SubtiList



Categories containing this gene/protein

DNA repair/ recombination

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU17050

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: DNA mismatch repair mutL/hexB family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Localization:
    • forms foci at midcell position, the frequency of foci increases upon mismatch formation PubMed

Database entries

  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:

Biological materials

  • Mutant: GP1190 (del mutSL::aphA3) available in the Stülke lab
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Additional publications: PubMed

Monica C Pillon, Jessica J Lorenowicz, Michael Uckelmann, Andrew D Klocko, Ryan R Mitchell, Yu Seon Chung, Paul Modrich, Graham C Walker, Lyle A Simmons, Peter Friedhoff, Alba Guarné
Structure of the endonuclease domain of MutL: unlicensed to cut.
Mol Cell: 2010, 39(1);145-51
[PubMed:20603082] [WorldCat.org] [DOI] (I p)

Irnov Irnov, Cynthia M Sharma, Jörg Vogel, Wade C Winkler
Identification of regulatory RNAs in Bacillus subtilis.
Nucleic Acids Res: 2010, 38(19);6637-51
[PubMed:20525796] [WorldCat.org] [DOI] (I p)

Mario Pedraza-Reyes, Ronald E Yasbin
Contribution of the mismatch DNA repair system to the generation of stationary-phase-induced mutants of Bacillus subtilis.
J Bacteriol: 2004, 186(19);6485-91
[PubMed:15375129] [WorldCat.org] [DOI] (P p)

F Ginetti, M Perego, A M Albertini, A Galizzi
Bacillus subtilis mutS mutL operon: identification, nucleotide sequence and mutagenesis.
Microbiology (Reading): 1996, 142 ( Pt 8);2021-9
[PubMed:8760914] [WorldCat.org] [DOI] (P p)