SigH

• Description: RNA polymerase sigma factor SigH
  
  

Gene name	sigH
Synonyms	spo0H
Essential	no
Product	RNA polymerase sigma factor SigH
Function	transcription of early stationary phase genes (sporulation, competence)
Interactions involving this protein in SubtInteract: SigH
MW, pI	25 kDa, 5.146
Gene length, protein length	654 bp, 218 aa
Immediate neighbours	yacP, rpmGB
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

transcription, sigma factors and their control

This gene is a member of the following regulons

AbrB regulon

The gene

Basic information

• Locus tag: BSU00980

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: sigma-70 factor family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions: (RpoB-RpoC)-SigH

• Localization:

Database entries

• Structure:

• UniProt: P17869

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: sigH (DBTBS)

• Sigma factor: SigA PubMed

• Regulation:
  • repressed during logrithmic growth (AbrB) PubMed

• Regulatory mechanism:
  • AbrB: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

• Charles Moran, Emory University, NC, USA homepage

References

Reviews

Michiel J L de Hoon, Patrick Eichenberger, Dennis Vitkup
Hierarchical evolution of the bacterial sporulation network.
Curr Biol: 2010, 20(17);R735-45
[PubMed:20833318] [WorldCat.org] [DOI] (I p)

The SigH regulon

Robert A Britton, Patrick Eichenberger, Jose Eduardo Gonzalez-Pastor, Paul Fawcett, Rita Monson, Richard Losick, Alan D Grossman
Genome-wide analysis of the stationary-phase sigma factor (sigma-H) regulon of Bacillus subtilis.
J Bacteriol: 2002, 184(17);4881-90
[PubMed:12169614] [WorldCat.org] [DOI] (P p)