SasA

• Description: (p)ppGpp synthetase, small alarmone synthetase
  
  

Gene name	ywaC
Synonyms	ipa-7d
Essential	no
Product	(p)ppGpp synthetase
Function	ppGpp synthesis independent from stringent response
MW, pI	24 kDa, 6.217
Gene length, protein length	630 bp, 210 aa
Immediate neighbours	ywaD, menA
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU38480

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

Categories containing this gene/protein

metabolism of signalling nucleotides, cell envelope stress proteins (controlled by SigM, W, X, Y)

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s): YjbM

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P39583

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: ywaC PubMed

• Sigma factor: SigW PubMed

• Regulation: Transcription is highly upregulated in response to lesions in late-acting teichoic acid synthesis genes tagB, tagD and tagF, and also in response to cell-wall-active compounds like bacitracin or vancomycin PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: