ParA

• Description: centromere-like function involved in forespore chromosome partitioning / negative regulation of sporulation initiation
  
  

Gene name	soj
Synonyms	spo0JA
Essential	no
Product	negative regulator of sporulation initiation
Function	forespore chromosome partitioning / negative regulation of sporulation initiation
MW, pI	27 kDa, 4.903
Gene length, protein length	759 bp, 253 aa
Immediate neighbours	spo0J, yyaB
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU40970

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

Categories containing this gene/protein

DNA condensation/ segregation, sporulation/ other, membrane proteins

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: parA family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • polar/ septal at the cell membrane PubMed
  • polar localization depends on the proton motive force PubMed

Database entries

• Structure:

• UniProt: P37522

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: soj-spo0J (according to DBTBS)

• Sigma factor:

• Regulation:
  • repressed under conditions that trigger sporulation (Spo0A) PubMed

• Regulatory mechanism:
  • Spo0A: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Tsutomu Katayama, Shogo Ozaki, Kenji Keyamura, Kazuyuki Fujimitsu
Regulation of the replication cycle: conserved and diverse regulatory systems for DnaA and oriC.
Nat Rev Microbiol: 2010, 8(3);163-70
[PubMed:20157337] [WorldCat.org] [DOI] (I p)