Difference between revisions of "HemQ"
| Line 1: | Line 1: | ||
| − | * '''Description:''' | + | * '''Description:''' heme-binding protein, essential for heme biosynthesis <br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
|- | |- | ||
|style="background:#ABCDEF;" align="center"|'''Gene name''' | |style="background:#ABCDEF;" align="center"|'''Gene name''' | ||
| − | |'' | + | |''hemQ'' |
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''ipa-87r '' | + | |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''ipa-87r, ywfI '' |
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''Essential''' || no | |style="background:#ABCDEF;" align="center"| '''Essential''' || no | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"| '''Product''' || | + | |style="background:#ABCDEF;" align="center"| '''Product''' || heme-binding protein |
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"|'''Function''' || | + | |style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of heme |
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 29 kDa, 4.972 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 29 kDa, 4.972 | ||
| Line 38: | Line 38: | ||
===Phenotypes of a mutant === | ===Phenotypes of a mutant === | ||
| + | defect in heme biosynthesis | ||
=== Database entries === | === Database entries === | ||
| Line 66: | Line 67: | ||
* '''Modification:''' phosphorylation on Ser-41 [http://www.ncbi.nlm.nih.gov/sites/entrez/17218307 PubMed] | * '''Modification:''' phosphorylation on Ser-41 [http://www.ncbi.nlm.nih.gov/sites/entrez/17218307 PubMed] | ||
| − | * '''Cofactor(s):''' | + | * '''Cofactor(s):''' heme |
* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
| Line 118: | Line 119: | ||
=References= | =References= | ||
| − | <pubmed>17218307, 9353933 </pubmed> | + | <pubmed>17218307, 9353933 20543190 </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 15:28, 15 June 2010
- Description: heme-binding protein, essential for heme biosynthesis
| Gene name | hemQ |
| Synonyms | ipa-87r, ywfI |
| Essential | no |
| Product | heme-binding protein |
| Function | biosynthesis of heme |
| MW, pI | 29 kDa, 4.972 |
| Gene length, protein length | 762 bp, 254 aa |
| Immediate neighbours | pta, ywfH |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU37670
Phenotypes of a mutant
defect in heme biosynthesis
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: UPF0447 family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification: phosphorylation on Ser-41 PubMed
- Cofactor(s): heme
- Effectors of protein activity:
- Interactions:
- Localization:
Database entries
- Structure: 1TOT (Geobacillus stearothermophilus)
- UniProt: P39645
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: ywfI PubMed
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Tamara A Dailey, Tye O Boynton, Angela-Nadia Albetel, Svetlana Gerdes, Michael K Johnson, Harry A Dailey
Discovery and Characterization of HemQ: an essential heme biosynthetic pathway component.
J Biol Chem: 2010, 285(34);25978-86
[PubMed:20543190]
[WorldCat.org]
[DOI]
(I p)
Boris Macek, Ivan Mijakovic, Jesper V Olsen, Florian Gnad, Chanchal Kumar, Peter R Jensen, Matthias Mann
The serine/threonine/tyrosine phosphoproteome of the model bacterium Bacillus subtilis.
Mol Cell Proteomics: 2007, 6(4);697-707
[PubMed:17218307]
[WorldCat.org]
[DOI]
(P p)
E Presecan, I Moszer, L Boursier, H Cruz Ramos, V de la Fuente, M-F Hullo, C Lelong, S Schleich, A Sekowska, B H Song, G Villani, F Kunst, A Danchin, P Glaser
The Bacillus subtilis genome from gerBC (311 degrees) to licR (334 degrees).
Microbiology (Reading): 1997, 143 ( Pt 10);3313-3328
[PubMed:9353933]
[WorldCat.org]
[DOI]
(P p)
