bacG
168

short chain reductase involved in bacilysin synthesis

Locus

BSU_37680

Molecular weight

27.87 kDa

Isoelectric point

6.6

Protein length

259 aaSequenceBlast

Gene length

780 bpSequenceBlast

Function

biosynthesis of the antibiotic bacilysin

Product

short chain reductase

Essential

Synonyms

bacG, ipa-86r, ywfH

Outlinks

BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Hide small RNAsZoom:

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1028 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene

Coordinates

3,867,493 → 3,868,272

The protein

Catalyzed reaction/ biological activity

BacG catalyzes the conjugate addition of hydride at the C4 olefinic terminus using NADH to yield the cyclohexenol- containing tetrahydro-4-hydroxyphenylpyruvate PubMed

stereoselective reduction of dihydro-hydroxyphenylpyruvate (H2HPP) to tetrahydro-hydroxyphenylpyruvate (H4HPP), NADPH-dependent reductase that facilitates the conjugate addition of a hydride at the C(4) olefin terminus of H2HPP PubMed

Protein family

Short-chain dehydrogenases/reductases (SDR) family (according to UniProt)

Cofactors

NADPH PubMed

Structure

3U49 (PDB) PubMed

P39644 (AlphaFold)

Expression and Regulation

Operons

Genes

bacG

Description