Difference between revisions of "DnaN"
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| − | * '''Description:''' DNA polymerase III (beta subunit), beta clamp, part of the [[replisome]] <br/><br/> | + | * '''Description:''' DNA polymerase III (beta subunit), beta clamp, part of the [[replisome]], also involved in DNA mismatch repair <br/><br/> |
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|style="background:#ABCDEF;" align="center"| '''Product''' || DNA polymerase III <br/>(beta subunit), beta clamp | |style="background:#ABCDEF;" align="center"| '''Product''' || DNA polymerase III <br/>(beta subunit), beta clamp | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"|'''Function''' || DNA replication | + | |style="background:#ABCDEF;" align="center"|'''Function''' || DNA replication, DNA repair |
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 41 kDa, 4.718 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 41 kDa, 4.718 | ||
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<pubmed> 20157337 </pubmed> | <pubmed> 20157337 </pubmed> | ||
==Original publications== | ==Original publications== | ||
| − | <pubmed>16942601 9822387 14651647,2987848 2168872 14651647 12060778 16461910, 16479537 19737352 19081080 11395445 20122408 </pubmed> | + | <pubmed>16942601 9822387 14651647,2987848 2168872 14651647 12060778 16461910, 16479537 19737352 19081080 11395445 20122408 20451384 </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 16:27, 11 May 2010
- Description: DNA polymerase III (beta subunit), beta clamp, part of the replisome, also involved in DNA mismatch repair
| Gene name | dnaN |
| Synonyms | dnaG, dnaK |
| Essential | yes PubMed |
| Product | DNA polymerase III (beta subunit), beta clamp |
| Function | DNA replication, DNA repair |
| MW, pI | 41 kDa, 4.718 |
| Gene length, protein length | 1134 bp, 378 aa |
| Immediate neighbours | dnaA, yaaA |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU00020
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1) (according to Swiss-Prot)
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions: DnaA-YabA-DnaN PubMed, part of the replisome: PolC-HolA-HolB-DnaX-DnaN-DnaG-DnaC-DnaI-DnaD-SsbA-DnaE-PriA-DnaB PubMed
Database entries
- Structure:
- UniProt: P05649
- KEGG entry: [3]
- E.C. number: 2.7.7.7
Additional information
Expression and regulation
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Philippe Noirot, Jouy-en-Josas, France homepage
Your additional remarks
References
Reviews
Tsutomu Katayama, Shogo Ozaki, Kenji Keyamura, Kazuyuki Fujimitsu
Regulation of the replication cycle: conserved and diverse regulatory systems for DnaA and oriC.
Nat Rev Microbiol: 2010, 8(3);163-70
[PubMed:20157337]
[WorldCat.org]
[DOI]
(I p)
Original publications
