Difference between revisions of "TrxA"

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(References)
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* '''Effectors of protein activity:'''
 
* '''Effectors of protein activity:'''
  
* '''Interactions:''' [[TrxA]]-[[ArsC]]
+
* '''Interactions:''' [[ArsC]]-[[TrxA]] {{PubMed|17303556}}
  
 
* '''Localization:''' cytoplasm (according to Swiss-Prot)
 
* '''Localization:''' cytoplasm (according to Swiss-Prot)
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=== Database entries ===
 
=== Database entries ===
  
* '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=2GZZ 2GZZ] (oxidized form),  [http://www.rcsb.org/pdb/explore.do?structureId=2GZY 2GZY] (reduced form),  [http://www.rcsb.org/pdb/explore.do?structureId=2IPA 2IPA] (TrxA-ArsC-complex)
+
* '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=2GZZ 2GZZ] (oxidized form),  [http://www.rcsb.org/pdb/explore.do?structureId=2GZY 2GZY] (reduced form),  [http://www.rcsb.org/pdb/explore.do?structureId=2IPA 2IPA] (TrxA-ArsC-complex) {{PubMed|17303556}}
  
 
* '''UniProt:''' [http://www.uniprot.org/uniprot/P14949 P14949]
 
* '''UniProt:''' [http://www.uniprot.org/uniprot/P14949 P14949]
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=References=
 
=References=
  
<pubmed>9537387,15937154,18601268,18456801,9852015 ,11544224,18687074 20084284 </pubmed>
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<pubmed>9537387,15937154,18601268,18456801,9852015 ,11544224,18687074 20084284 17303556</pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 06:40, 24 February 2010

  • Description: antioxidative action by facilitating the reduction of other proteins by cysteine thiol-disulfide exchange

Gene name trxA
Synonyms trx
Essential yes PubMed
Product thioredoxin
Function protection of proteins against oxidative damage
MW, pI 11 kDa, 4.308
Gene length, protein length 312 bp, 104 aa
Immediate neighbours uvrC, abf2
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
TrxA context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU28500

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: thioredoxin family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Localization: cytoplasm (according to Swiss-Prot)

Database entries

  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • induced by stress (SigB) PubMed
    • regulation by Spx in response to diamide stress
    • induced by heat stress (CtsR) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References