ymfI

ymfI
168

Efp-5 aminopentanone reductase

Locus
BSU_16870
Molecular weight
25.43 kDa
Isoelectric point
5.22
Protein length
242 aaSequenceBlast
Gene length
729 bpSequenceBlast
Function
modification of Efp
Product
Efp-5 aminopentanone reductase
Essential
no
Synonyms
ymfI
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1028 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,759,655  1,760,383
Phenotypes of a mutant
defective in Swarming motility PubMed, this can be suppressed by mutations affecting earlier steps in Efp modification (gsaB, yaaO, yfkA, ynbB, ywlG) PubMed
The protein
Catalyzed reaction/ biological activity
reduction of Efp-5 aminopentanone to Efp-5 aminopentanol PubMed
Protein family
Short-chain dehydrogenases/reductases (SDR) family (according to UniProt)
Cofactors
NADPH PubMed
Structure
2PNF (PDB) (from Aquifex Aeolicus , 36% identity)
O31767 (AlphaFold)
Paralogous protein(s)
YhxC, YcdF, YhdF
FabG, (34%)
YjdA, (30,8%)
Biological materials
Mutant
MGNA-B379 (ymfI::erm), available at the NBRP B. subtilis, Japan
BKE16870 (ymfI::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCCTCTTTCCTTCTTTCC,  downstream forward: _UP4_TGATCCGAAAATATTCGGTG
BKK16870 (ymfI::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCCTCTTTCCTTCTTTCC,  downstream forward: _UP4_TGATCCGAAAATATTCGGTG
References
Research papers
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Time of last update: 2025-04-02 01:54:56

Author of last update: Jstuelk