MhqR

• Description: MarR-family transcriptional repressor of azoR2, mhqA, mhqD-mhqE and mhqN-mhqO-mhqP expression
  
  

Gene name	mhqR
Synonyms	ykvE
Essential	no
Product	MarR-family transcriptional repressor
Function	regulation of resistance to quinones and diamide
Gene expression levels in SubtiExpress: mhqR
MW, pI	16 kDa, 6.42
Gene length, protein length	435 bp, 145 aa
Immediate neighbours	kinD, motB
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transcription factors and their control, resistance against oxidative and electrophile stress

The MhqR regulon

• azoR2, mhqA, mhqD-mhqE and mhqN-mhqO-mhqP

The gene

Basic information

• Locus tag: BSU13670

Phenotypes of a mutant

• resistant to quinones and diamide

Database entries

• BsubCyc: BSU13670

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• BsubCyc: BSU13670

• Structure:

• UniProt: O31672

• KEGG entry: [2]

• E.C. number:

Additional information

• Binding site: tATCTcgaAtTCgAGATaaaa PubMed

Expression and regulation

• Operon:

• Expression browser: mhqR PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Haike Antelmann,University of Greifswald, Germany

Reviews

Haike Antelmann, Michael Hecker, Peter Zuber
Proteomic signatures uncover thiol-specific electrophile resistance mechanisms in Bacillus subtilis.
Expert Rev Proteomics: 2008, 5(1);77-90
[PubMed:18282125] [WorldCat.org] [DOI] (I p)

Original articles

Stefanie Töwe, Montira Leelakriangsak, Kazuo Kobayashi, Nguyen Van Duy, Michael Hecker, Peter Zuber, Haike Antelmann
The MarR-type repressor MhqR (YkvE) regulates multiple dioxygenases/glyoxalases and an azoreductase which confer resistance to 2-methylhydroquinone and catechol in Bacillus subtilis.
Mol Microbiol: 2007, 66(1);40-54
[PubMed:17725564] [WorldCat.org] [DOI] (P p)