spsC

spsC
168

aminotransferase, legionaminic acid synthesis

Locus
BSU_37890
Molecular weight
43.03 kDa
Isoelectric point
5.55
Protein length
389 aaSequenceBlast
Gene length
1170 bpSequenceBlast
Function
legionaminic acid synthesis
Product
aminotransferase
Essential
no
Synonyms
spsC, ipa-65d
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0399 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,889,732  3,890,901
Phenotypes of a mutant
the mutant tends to acquire suppressor mutations that result in improved growth PubMed
less hydrophobic spore surface PubMed
The protein
Catalyzed reaction/ biological activity
legionaminic acid synthesis PubMed
Protein family
DegT/DnrJ/EryC1 family (with EpsN and NtdA, according to UniProt)
Cofactors
PLP PubMed
Structure
1MDX (PDB) (ArnB from Salomonella typhimurium, 44% identity) PubMed
P39623 (AlphaFold)
Localization
binds the outer surface of the forming spore PubMed
Expression and Regulation
Operons
Genes
spsA-spsB-spsC-spsD-spsE-spsF-spsG-spsI-spsJ-spsK-spsL
Description
PubMed
Regulation
expressed during sporulation in the mother cell (SigE, SigK, GerE) PubMed
Regulatory mechanism
GerE: activation, PubMed, in gerE regulon
Sigma factors
SigE: sigma factor, PubMed, in sigE regulon
SigK: sigma factor, PubMed, in sigK regulon
Additional information
the mRNA is very stable (half-life > 15 min) PubMed
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spsA→spsL

2025-04-07 10:32:08

ghost

135

8fd40e70daa9bc3b7d469fa252e122a98e4555de

9FCD794B68194823BCA66D7E89CC93E5AF9CC0AA

Biological materials
Mutant
CS218 (''spsC::aphA3'', available in Colin Harwood's and Jörg Stülke's labs) PubMed
BKE37890 (spsC::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTTCTTTGCGCTCCTATC,  downstream forward: _UP4_GATATCGTAAAAGGGGCTGA
BKK37890 (spsC::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTTCTTTGCGCTCCTATC,  downstream forward: _UP4_GATATCGTAAAAGGGGCTGA
References
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38DBA751456A0C0EC5D028939ADB8860ADA28F94

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Time of last update: 2025-04-16 22:43:38

Author of last update: Jstuelk