med

med
168

lipoprotein, positive regulator of comK, stimulates KinD-dependent phosphorylation of Spo0A

Locus
BSU_11300
Molecular weight
35.16 kDa
Isoelectric point
4.6
Protein length
317 aaSequenceBlast
Gene length
954 bpSequenceBlast
Function
regulation of competence
Product
positive regulator of comK
Essential
no
Synonyms
med, yjaW
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1744 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,206,629  1,207,582
Phenotypes of a mutant
impaired biofilm formation PubMed
The protein
Catalyzed reaction/ biological activity
stimulates KinD-dependent phosphorylation of Spo0A PubMed
Protein family
BMP lipoprotein family (with NupN, according to UniProt)
Structure
2HQB (PDB) (from B. halodurans, 49% identity) PubMed
O32436 (AlphaFold)
Localization
cell surface PubMed
Expression and Regulation
Operons
Genes
yjaV-med-comZ
Description
PubMed
Sigma factors
SigE: sigma factor, PubMed, in sigE regulon
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yjaV->comZ

2025-03-07 23:25:48

Bzhu

109

96bbde0fab9686c9611ee937310c9ee14bc9660c

229F31AF8CB2DB513EEB5E7E9812DC533EF51AEE

Genes
med-comZ
Description
PubMed
Regulation
repressed under conditions that trigger sporulation (Spo0A) PubMed
Regulatory mechanism
Spo0A: repression, PubMed, in spo0A regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
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med→comZ

2025-03-07 22:41:21

ghost

74

59ed9d4827fed8cc173654932418cb19c7fa8d5d

73AE85AA2203B05C4FE3B47EFB655AD7999F34DB

Genes
yjaU-yjaV-med-comZ
Description
PubMed
Open in new tab

yjaU->comZ

2025-03-07 22:41:31

Jstuelk

77

d691d7285529fe70ca653bff9af1cfb1b815b70a

C6B12BC76A78C50ADA8A84738A7AF27D7330A58B

Biological materials
Mutant
BKE11300 (med::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAAGTCATGTTCAACTCCTT,  downstream forward: _UP4_AACGAGTAATGGAGTGACGT
BKK11300 (med::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAAGTCATGTTCAACTCCTT,  downstream forward: _UP4_AACGAGTAATGGAGTGACGT
References
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4DAB7847EA3848A34432C80124464543FA3DCA0F

Page visits: 3306

Time of last update: 2025-04-01 23:02:59

Author of last update: Melvin.boenninger