gltR

gltR
168

transcriptional regulator (LysR family)

Locus
BSU_26670
Molecular weight
32.79 kDa
Isoelectric point
6.65
Protein length
296 aaSequenceBlast
Gene length
891 bpSequenceBlast
Function
unknown
Product
transcriptional regulator (LysR family)
Essential
no
Synonyms
gltR, yrdL
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0583 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,725,837  2,726,727
Phenotypes of a mutant
The function of this protein is unknown. However, certain mutant forms are able to activate expression of the gltA-gltB operon (and thus to replace the cognate activator protein GltC) PubMed
The protein
Protein family
LysR family (according to UniProt)
Domains
HTH lysR-type domain (aa 1-58) (according to UniProt)
Structure
5Z72 (PDB) (B. amyloliquefaciens CcpC, 22% identity)
P94501 (AlphaFold)
Additional information
The function of this protein is unknown. However, certain mutant forms are able to activate expression of the gltA-gltB operon (and thus to replace the cognate activator protein GltC) PubMed
information on binding sites can be found in the PRODORIC2 database
Expression and Regulation
Operons
Genes
gltR
Description
(according to DBTBS) null
Regulatory mechanism
GltR: negative autoregulation, in gltR regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
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gltR

2025-03-16 02:15:56

ghost

70

17f9a26e007d5901ef7ace5383167c2a4873698b

56EB4B4647B35089F854744A28877DB11519EBE7

Biological materials
Mutant
GP3615 (spec), available in Jörg Stülke's lab PubMed
GP345 (erm), available in Jörg Stülke's lab
BKE26670 (gltR::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCTAGTCCTCCATAGTTG,  downstream forward: _UP4_TAAATAAATGGATGGAAGGC
BKK26670 (gltR::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCTAGTCCTCCATAGTTG,  downstream forward: _UP4_TAAATAAATGGATGGAAGGC
Expression vectors
pBP421 (N-terminal Strep-tag, for SPINE, purification from B. subtilis, in pGP382) (available in Fabian Commichau's lab)
Labs working on this gene/protein
Linc Sonenshein, Tufts University, Boston, MA, USA Homepage
References
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Page visits: 2454

Time of last update: 2025-04-17 02:30:26

Author of last update: Jstuelk