ycbH

ycbH
168

galactarate dehydratase

Locus
BSU_02510
Molecular weight
54.63 kDa
Isoelectric point
5.7
Protein length
510 aaSequenceBlast
Gene length
1533 bpSequenceBlast
Function
galactarate utilization
Product
galactarate dehydratase
Essential
no
E.C.
4.2.1.42
Synonyms
ycbH, garD
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2721 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
274,029 → 275,561
The protein
Catalyzed reaction/ biological activity
galactarate --> 5-dehydro-4-deoxy-D-glucarate + H2O (according to UniProt)
Protein family
uxaA family (with UxaA, according to UniProt)
Structure
6U7L (PDB) (from E. coli, 67.6% identity)
P42240 (AlphaFold)
Expression and Regulation
Operons
Genes
ycbC-ycbD-ycbE-ycbF-ycbG-ycbH-ycbJ
Description
PubMed
Regulation
induced by D-glucarate/galactarate (YcbG) PubMed
Regulatory mechanism
YcbG: repression, PubMed, in ycbG regulon
AbrB: repression, PubMed, in abrB regulon
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ycbC→ycbJ

2025-03-10 23:53:20

ghost

122

a8e395a36da4d417bafa3e16f332fbbf2dcf2e61

24EBFC92FB6A93BD115AC81FF68694FB539EE76E

Biological materials
Mutant
MGNA-C031 (ycbH::erm), available at the NBRP B. subtilis, Japan
BKE02510 (ΔycbH::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATATGAAAATCACTCCTCA,  downstream forward: _UP4_TGATTCATGTTTTTATAGCG
BKK02510 (ΔycbH::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATATGAAAATCACTCCTCA,  downstream forward: _UP4_TGATTCATGTTTTTATAGCG
References
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BA556E144975921DFDD598B0A7480C65176F0F14

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Time of last update: 2025-04-02 23:13:26

Author of last update: Jstuelk