comS
168

antiadaptor protein, assembly link between regulatory components of the competence signal transduction pathway

Locus

BSU_03500

Molecular weight

5.11 kDa

Isoelectric point

9.15

Protein length

46 aaSequenceBlast

Gene length

141 bpSequenceBlast

Function

control of ComK degradation

Product

antiadaptor protein (anti-MecA)

Essential

Synonyms

comS

Outlinks

BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

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Categories containing this gene/protein

List of homologs in different organisms

This gene is a member of the following regulons

Gene

Coordinates

390,880 391,020

Phenotypes of a mutant

loss of genetic competence PubMed

overexpression of ComS results in expression of competence genes in 80% to 90% of the cells PubMed

The protein

Structure

P80355 (AlphaFold)

Expression and Regulation

Operons

Genes

srfAA-srfAB-comS-srfAC-srfAD

Description

PubMed

Regulation

expressed at high cell density (ComA) PubMed

heterogeneous expression, percentage of expressing cells increases during colonization of plant roots PubMed

Regulatory mechanism

PhoP: activation, PubMed, in phoP regulon

CodY: repression, PubMed, in codY regulon

ComA: activation, PubMed, in comA regulon

PerR: activation, PubMed, in perR regulon

Spx: repression, PubMed, in spx regulon

Abh: repression, PubMed, in abh regulon

Sigma factors

SigA: sigma factor, PubMed, in sigA regulon

Additional information

A ncRNA is predicted between 'HxlR' and 'SrfAA' PubMed

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Biological materials

Mutant

BKE03500 (comS::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CTTGCCTGATCGGTTCAAACG, downstream forward: _UP4_AAGTAGATAAAGACCGGCTTG

BKK03500 (comS::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CTTGCCTGATCGGTTCAAACG, downstream forward: _UP4_AAGTAGATAAAGACCGGCTTG

References

Reviews

Original Publications

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Time of last update: 2025-04-02 00:36:05

Author of last update: Bzhu

comS 168

comS
168