fosB

fosB
168

bacillithiol-S-transferase; confers resistence against antimicrobial compounds from B. amyloliquefaciens

Locus
BSU_17840
Molecular weight
17.03 kDa
Isoelectric point
6.14
Protein length
144 aaSequenceBlast
Gene length
435 bpSequenceBlast
Function
confers resistence against antimicrobial compounds from B. amyloliquefaciens
Product
fosfomycin resistance protein
Essential
no
Synonyms
fosB, yndN
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0346 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,916,663  1,917,097
Phenotypes of a mutant
sensitive to fosfomycin PubMed
The protein
Protein family
fosfomycin resistance protein family (single member, according to UniProt)
Domains
VOC domain (aa 5-120) (according to UniProt)
Cofactors
Mg2+ PubMed
Structure
4JD1 (PDB) (from B. anthracis, 66% identity)
O31817 (AlphaFold)
Localization
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
Genes
fosB
Description
PubMed
Regulation
expressed under stress conditions (SigW) PubMed
Sigma factors
SigW: sigma factor, PubMed, in sigW regulon
Additional information
A ncRNA is predicted between 'fosB' and 'lexA' PubMed
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fosB

2025-03-13 16:35:20

ghost

67

2b973ec1127729d9437d7fcdd76e683b0527e57d

3C87BDB08AFCCBE32D44129BF78488366D678475

Biological materials
Mutant
MGNA-B387 (yndN::erm), available at the NBRP B. subtilis, Japan
BKE17840 (fosB::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CACAAATCATTCCCCCCTTG,  downstream forward: _UP4_TGATAGCACAACCATATTTC
BKK17840 (fosB::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CACAAATCATTCCCCCCTTG,  downstream forward: _UP4_TGATAGCACAACCATATTTC
References
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92E4F908B7CDE64743796CCD3188FE6BB5288365

Page visits: 2697

Time of last update: 2025-04-03 15:34:33

Author of last update: Melvin.boenninger