mmgE

mmgE
168

2-methylcitrate dehydratase

Locus
BSU_24130
Molecular weight
52.74 kDa
Isoelectric point
6.11
Protein length
472 aaSequenceBlast
Gene length
1419 bpSequenceBlast
Function
mother cell metabolism
Product
2-methylcitrate dehydratase
Essential
no
E.C.
4.2.1.79
Synonyms
mmgE, yqiP, prpD
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2079 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,508,221  2,509,639
The protein
Catalyzed reaction/ biological activity
2-methylcitrate --> 2-methylaconitate PubMed
citrate --> cis-aconitate + H2O (according to UniProt)
Protein family
prpD family (with YxeQ, according to UniProt)
Cofactors
Fe-S cluster PubMed
Structure
5MUX (PDB)
P45859 (AlphaFold)
Expression and Regulation
Operons
Genes
mmgA-mmgB-mmgC-mmgD-mmgE-mmgF
Description
PubMed
Regulation
expressed early during sporulation in the mother cell (SigE) PubMed
strongly expressed during oligotrophic growth PubMed
Regulatory mechanism
CcpA: repression, PubMed, in ccpA regulon
Sigma factors
SigE: sigma factor, PubMed, in sigE regulon
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mmgA→mmgF

2025-03-27 18:32:54

Jstuelk

110

be5c5568e93dc96bd335d396c9ced168a6874b5d

43FB5BE81B1A707E4F1C97099736CD2DD49A154C

Biological materials
Mutant
BKE24130 (mmgE::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_TTTCGGCATTCTACCAGCTC,  downstream forward: _UP4_ATGTAAAAGGGGGATTTTGT
BKK24130 (mmgE::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_TTTCGGCATTCTACCAGCTC,  downstream forward: _UP4_ATGTAAAAGGGGGATTTTGT
References
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602EAB591A550F68C14F35F6E5F0A91C3B997343

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Time of last update: 2025-04-02 18:19:03

Author of last update: Melvin.boenninger