parE

parE
168

subunit of DNA topoisomerase IV

Locus
BSU_18090
Molecular weight
72.83 kDa
Isoelectric point
6.17
Protein length
655 aaSequenceBlast
Gene length
1968 bpSequenceBlast
Function
chromosome segregation and compaction, resolution of head-on DNA replication-Transcription conflicts
Product
subunit of DNA topoisomerase IV
Essential
yes
E.C.
5.99.1.-
Synonyms
parE, grlB
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0187 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,933,477  1,935,444
Phenotypes of a mutant
essential PubMed
upon overexpression, topoisomerase IV (ParE-ParC) can take over the functions of the type 1A topoisomerases TopA and TopB PubMed
The protein
Catalyzed reaction/ biological activity
ATP-dependent breakage, passage and rejoining of double-stranded DNA (according to UniProt)
binds to abasic DNA lesions PubMed
Protein family
type II topoisomerase GyrB family (together with GyrB) (according to UniProt)
Domains
TOPRIM domain (aa 423-537) PubMed
Structure
4I3H (PDB) (the ParE-ParC complex from Streptococcus pneumoniae, 70% identity) PubMed
Q59192 (AlphaFold)
Paralogous protein(s)
GyrB
Localization
Nucleoid (Homogeneous) PubMed
uniformly distributed throughout the cell PubMed
Expression and Regulation
Operons
Genes
parE-parC
Description
PubMed
Regulation
induced by DNA damage (LexA) PubMed
Regulatory mechanism
LexA: repression, PubMed, in lexA regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
Additional information
term-seq has identified a potential novel regulatory RNA element including an intrinsic transcription terminator upstream of parE PubMed
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parE→parC

2025-03-17 15:59:57

Jstuelk

90

ab7136d4f9d85a7b135e9e137bb03989f977f93b

36D635694850D146D05580333BCD5451AC2B2E78

Biological materials
LacZ fusion
GP2550 (parE::lacZ cat, based on pAC5), available in Jörg Stülke's lab PubMed
References
Reviews
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Original Publications
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1901C52DCB24B3D53150F6926C14907AC1B75293

Page visits: 4000

Time of last update: 2025-04-02 05:54:26

Author of last update: Jstuelk