bceA

bceA
168

primary bacitracin resistance determinant, ABC transporter (ATP-binding protein), protects cell wall biosynthetic targets from inhibition by antimicrobial peptides

Locus
BSU_30380
Molecular weight
28.08 kDa
Isoelectric point
9.29
Protein length
253 aaSequenceBlast
Gene length
762 bpSequenceBlast
Function
protection of cell wall biosynthetic targets from inhibition by antimicrobial peptides
Product
ABC transporter (ATP-binding protein) for target protection of cell wall synthesis
Essential
no
Synonyms
bceA, ytsC
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1136 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,111,327  3,112,088
Phenotypes of a mutant
85-fold increased sensitivity to bacitracin PubMed
The protein
Catalyzed reaction/ biological activity
releaves intermediates of the lipid II cycle from the inhibitory interaction with antimicrobial peptides such as bacitracin PubMed
Protein family
ABC transporter family (according to UniProt)
Domains
ABC transporter domain (aa 4-243) (according to UniProt)
Structure
7TCG (PDB) (BceA-BceB) PubMed
8G3A (PDB) (BceA-BceB-BceS) PubMed
1L2T (PDB) (MJ0796 from \tMethanocaldococcus jannaschii , 38% identity) PubMed
O34697 (AlphaFold)
Effectors of protein activity
the activity of the BceA-BceB ABC transporter is inhibited by heptaprenyl pyrophosphate which accumulates in a ''ytpB'' mutant PubMed
Paralogous protein(s)
YknY, YtrE, YxdL, PsdA, YvrO
Localization
membrane associated (via BceB) PubMed
Expression and Regulation
Operons
Genes
bceA-bceB
Description
PubMed
Regulation
induced in the presence of bacitracin, plectasin, mersacidin and actagardine, already at very low levels of bacitracin (BceR) PubMed
Regulatory mechanism
BceR: activation, PubMed, in bceR regulon
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bceA→bceB

2025-03-25 18:46:39

ghost

106

82aefb4fbb9fc68f93e518da69b01bd8ff729fe6

34D10F148A3DBFC0AFB70F7B58E13B120EF4A646

Biological materials
Mutant
GP3218 Δ(bceR-bceS-bceA-bceB)::cat, available in Jörg Stülke's lab
MGNA-A167 (ytsC::erm), available at the NBRP B. subtilis, Japan
BKE30380 (bceA::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTTACGCAGTCTCCTTTA,  downstream forward: _UP4_CAAGGCGTGTTAGGCGGGGT
BKK30380 (bceA::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTTACGCAGTCTCCTTTA,  downstream forward: _UP4_CAAGGCGTGTTAGGCGGGGT
Labs working on this gene/protein
Susanne Gebhard, Bath UK
References
Reviews
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Original Publications
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8E0DE8FE7E9C12495C4DCADA74D838FED088867D

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Time of last update: 2025-04-03 02:24:50

Author of last update: Jstuelk