yvrA

yvrA
168

ABC transporter (ATP binding domain) for cobalamin

Locus
BSU_33160
Molecular weight
48.47 kDa
Isoelectric point
5.01
Protein length
442 aaSequenceBlast
Gene length
1329 bpSequenceBlast
Function
uptake of cobalamin
Product
ABC transporter (ATP binding domain)
Essential
no
Synonyms
yvrA
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1865 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,401,141  3,402,469
The protein
Protein family
ABC transporter superfamily (according to UniProt)
Structure
4G1U (PDB) (from Yersinia pestis, N-terminal domain, aa 1 .. 255, 41% identity) PubMed
O34631 (AlphaFold)
Expression and Regulation
Operons
Genes
yvrC-yvrB-yvrA-yvqK
Regulation
expression is decreased in the presence of cobalamin (vitamin B12) (B12 riboswitch) PubMed
Regulatory mechanism
B12 riboswitch: RNA switch, upon binding of B12 PubMed, in B12 riboswitch
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yvrC→yvqK

2025-03-16 18:02:52

Bzhu

85

d5cf8a042334d1018e1fad83cd0fed94b5767cca

C18E89D2382271B7EB10AFD69809C50D9ADDA3DC

Biological materials
Mutant
MGNA-B043 (yvrA::erm), available at the NBRP B. subtilis, Japan
BKE33160 (yvrA::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_TCCCGACAGCCCTTCTGCCT,  downstream forward: _UP4_TAAGTCTGTAAAGGAGATTC
BKK33160 (yvrA::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_TCCCGACAGCCCTTCTGCCT,  downstream forward: _UP4_TAAGTCTGTAAAGGAGATTC
References
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128EBAE9C14C7BB75173DF912853A6FCE86ABCE4

Page visits: 1910

Time of last update: 2025-04-02 02:35:13

Author of last update: Jstuelk