cssR

cssR
168

two-component response regulator (OmpR family), control of cellular responses to protein secretion stress

Locus
BSU_33010
Molecular weight
26.06 kDa
Isoelectric point
5.07
Protein length
225 aaSequenceBlast
Gene length
678 bpSequenceBlast
Function
control of cellular responses to protein secretion stress
Product
two-component response regulator (OmpR family)
Essential
no
Synonyms
cssR, yvqA
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0745 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,385,724  3,386,401
The protein
Protein family
OmpR family of two-component response regulators
Domains
Response regulatory domain (aa 4-117) (according to UniProt)
Structure
2OQR (PDB) (from Mycobacterium tuberculosis, 34% identity)
O32192 (AlphaFold)
Modification
phosphorylated by CssS on an Asp residue
Effectors of protein activity
phosphorylation likely affects DNA-binding activity
Localization
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
Genes
cssR-cssS
Description
PubMed
Regulation
expressed under conditions of secretion stress (CssR) PubMed
Regulatory mechanism
CssR: activation, PubMed, in cssR regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
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cssR→cssS

2025-04-04 08:16:04

ghost

96

d62586dd7176a72b7cf49ae683ed93d09bb4b382

2C457B4F2C19BB95984674749FFD2EB045C6C14F

Biological materials
Mutant
MGNA-B031 (yvqA::erm), available at the NBRP B. subtilis, Japan
BKE33010 (cssR::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAAGGCTCTTCACATCCTTT,  downstream forward: _UP4_TTCGGCTACAGGATGATGTC
BKK33010 (cssR::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAAGGCTCTTCACATCCTTT,  downstream forward: _UP4_TTCGGCTACAGGATGATGTC
References
Reviews
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Original Publications
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A40CD2C23A19860342F440284302EFFDAC09E88A

Page visits: 4713

Time of last update: 2025-04-08 17:58:22

Author of last update: Jstuelk