frlB

frlB
168

fructoselysine-6-P-glycosidase

Locus
BSU_32610
Molecular weight
36.72 kDa
Isoelectric point
5.44
Protein length
328 aaSequenceBlast
Gene length
987 bpSequenceBlast
Function
metabolism of aminoacylated fructose
Product
fructoselysine-6-P-glycosidase
Essential
no
Synonyms
frlB, yurP
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2222 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,351,110 3,352,096
The protein
Domains
2 SIS domains (aa 15-153, aa 181-311) (according to UniProt)
Structure
3EUA (PDB)
O32157 (AlphaFold)
Modification
phosphorylated on Arg-48 PubMed
Localization
membrane associated PubMed
Additional information
belongs to the 100 most abundant proteins PubMed
Expression and Regulation
Operons
Genes
frlB-frlO-frlN-frlM-frlD-frlP
Description
PubMed
Regulation
'' FrlB'': repressed during growth in the presence of branched chain amino acids (CodY) PubMed
induced in the absence of RnpM PubMed
Regulatory mechanism
CodY: repression, PubMed, PubMed, in codY regulon
FrlR: repression, PubMed, in frlR regulon
RnpM: unknown, PubMed, in rnpM regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
Additional information
the frlB-frlO-frlN-frlM-frlD-frlP operon is strongly downregulated in a cshA mutant PubMed
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frlB→frlP

2025-03-21 13:44:54

Jstuelk

128

1386d0b18bc93ba0b08e1c36531a0379aa199ac3

218EAE44649CE3CDE2633AF97E4CC56ABC5AA2E3

Genes
frlB
Description
PubMed
Regulation
'' frlB'': repressed during growth in the presence of branched chain amino acids (CodY) PubMed
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frlB

2025-03-16 04:55:02

ghost

75

6f545c025b50310a628d8db60a8df51a0ef7a4ce

DBAF12DE789DB131AB5059743664BD1CC1257D77

Biological materials
Mutant
MGNA-A594 (yurP::erm), available at the NBRP B. subtilis, Japan
BKE32610 (frlB::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CAAATCCTTCACTCCTCGTT, downstream forward: _UP4_TGATCTGAAAATGAAGAACC
BKK32610 (frlB::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CAAATCCTTCACTCCTCGTT, downstream forward: _UP4_TGATCTGAAAATGAAGAACC
References
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C87E74FB67B53DD1C68916AA121388C60CE66E92

Page visits: 7131

Time of last update: 2025-04-03 19:25:17

Author of last update: Jstuelk