hemD

hemD
168

uroporphyrinogen-III synthase

Locus
BSU_28140
Molecular weight
28.96 kDa
Isoelectric point
5.09
Protein length
262 aaSequenceBlast
Gene length
789 bpSequenceBlast
Function
heme biosynthesis
Product
uroporphyrinogen-III synthase
Essential
no
E.C.
4.2.1.75
Synonyms
hemD
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1587 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,875,173  2,875,961
The protein
Catalyzed reaction/ biological activity
hydroxymethylbilane --> H2O + uroporphyrinogen III (according to UniProt)
Protein family
uroporphyrinogen-III synthase family (single member, according to UniProt)
Structure
P21248 (AlphaFold)
Expression and Regulation
Operons
Genes
hemA-hemX-hemC-hemD-hemB-hemL
Description
PubMed
Regulation
induced by hydrogen peroxide (PerR) PubMed
Regulatory mechanism
PerR: repression, PubMed, in perR regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
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hemA→hemL

2025-03-29 16:29:02

ghost

108

64840dd729762069005c4bd541ed0ddec6e74ace

168BC8B91CBFE3EA050DA8A9187C8C67D6BBE4F9

Biological materials
Mutant
BKE28140 (hemD::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CACTGTTTTTCCTTTCAACG,  downstream forward: _UP4_ATGTCAAGAGAGGAAGAGAG
BKK28140 (hemD::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CACTGTTTTTCCTTTCAACG,  downstream forward: _UP4_ATGTCAAGAGAGGAAGAGAG
References
Reviews
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Original Publications
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33459D4389F85D60311FCE770BBA0ED9802BA342

Page visits: 2150

Time of last update: 2025-04-07 17:31:02

Author of last update: Melvin.boenninger