yqgN

yqgN
168

5,10-methenyltetrahydrofolate synthetase, 5-formyltetrahydrofolate cyclo-ligase paralog implicated in thiamin metabolism

Locus
BSU_24890
Molecular weight
21.27 kDa
Isoelectric point
5.79
Protein length
187 aaSequenceBlast
Gene length
564 bpSequenceBlast
Function
detoxification of 5-formyl-THF
Product
5,10-methenyltetrahydrofolate synthetase
Essential
no
E.C.
null
Synonyms
yqgN
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0212 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,573,760 → 2,574,323
The protein
Catalyzed reaction/ biological activity
converts toxic 5-formyl-THF (side product of GlyA) back to 5,10-methenyl-THF PubMed
Protein family
5-formyltetrahydrofolate cyclo-ligase family (single member, according to UniProt)
Structure
1YDM (PDB)
P54491 (AlphaFold)
Biological materials
Mutant
MGNA-C460 (yqgN::erm), available at the NBRP B. subtilis, Japan
BKE24890 (ΔyqgN::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCTCTCATCCCCCTCGGA,  downstream forward: _UP4_TAACTTTCCTGTCCCTTATT
BKK24890 (ΔyqgN::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCTCTCATCCCCCTCGGA,  downstream forward: _UP4_TAACTTTCCTGTCCCTTATT
Original Publications
Loading

CB9728D2A23C8F03104FF781D514CB3E6169835E

Page visits: 1236

Time of last update: 2025-04-06 07:38:21

Author of last update: Jstuelk