pksM

pksM
168

polyketide synthase

Locus
BSU_17200
Molecular weight
475.31 kDa
Isoelectric point
5.31
Protein length
4262 aaSequenceBlast
Gene length
12789 bpSequenceBlast
Function
polyketide synthesis
Product
polyketide synthase
Essential
no
E.C.
null
Synonyms
pksM
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG3321 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,821,553  1,834,341
The protein
Domains
4 Carrier domains (aa 293-367, aa 2188-2261, aa 3409-3486, aa 4135-4212) (according to UniProt)
Structure
6MHK (PDB) (from B. amyloliquefacies, corresponds to aa 395 ... 994, 2321 ... 2902, 3532 ... 4110, 73% identity)
Expression and Regulation
Operons
Genes
pksC-pksD-pksE-acpK-pksF-pksG-pksH-pksI-pksJ-pksL-pksM-pksN-pksR
Description
PubMed
Regulation
expressed during the transition from growth to stationary phase (AbrB, CodY) PubMed
heterogeneous expression, percentage of expressing cells increases during colonization of plant roots PubMed
Regulatory mechanism
AbrB: repression, PubMed, in abrB regulon
CodY: activation, PubMed, in codY regulon
Additional information
this is a very large operon comprising about 75 kb
Open in new tab

pksC→pksR

2025-04-08 14:15:58

Jstuelk

163

74BF817D9000509D225BBBCAC6C8A0A9EABEB843

1475C94AAA2C10C6BE3CA0873EFBD171EC2E2513

Genes
pksB-pksC-pksD-pksE-acpK-pksF-pksG-pksH-pksI-pksJ-pksL-pksM-pksN-pksR
Description
PubMed
Open in new tab

pksB→pksR

2025-04-08 20:08:07

Jstuelk

137

c851e07b7201353cf026d8929ea66cff6bbb92e2

D95CF77A7673AA84CC653095A1FB017D490049D6

Biological materials
Mutant
BKE17200 (pksM::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_AGTTATCATTTTCCCACTCC,  downstream forward: _UP4_TAAAGAAATTCTCGATGCCT
BKK17200 (pksM::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_AGTTATCATTTTCCCACTCC,  downstream forward: _UP4_TAAAGAAATTCTCGATGCCT
References
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40779D3A6E4F72EEFD702BF9FA15B57951783D12

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Time of last update: 2025-04-05 22:36:03

Author of last update: Jstuelk