SigM regulon

Regulator	SigM
Overview on the regulons (wiki page) Overview on the regulons (Excel file)

• The SigM regulon is induced by cell wall-active antibiotics like vancomycin and bacitracin, as well as a variety of other stresses
• Expression of the SigM regulon in increased in ugtP mutants PubMed

Genes in this regulon

• abh
• amj
• bcrC
• coaX
• ddl-murF
• disA
• divIC
• dltA-dltB-dltC-dltD-dltE
• fatR
• ftsH
• hprT
• ispD
• metA
• radC-mreB-mreC-mreD-minC-minD
• murB-divIB-ylxX-ylxW-sbp
• pbpX
• rapD
• recU-ponA
• rodA
• sasA
• secDF
• sigM-yhdL-yhdK
• spx
• tagT
• tagU
• tilS
• ugtP
• yacC
• yacL
• yceC-yceD-yceE-yceF
• yceG
• yceH
• ycgQ
• ycgR
• yebC
• yfnI
• yjbC
• yngC
• ypbG
• ypuA
• ypuD
• yqjL
• yrhH
• yrhJ
• ytpA-ytpB
• ywbN
• ywbO
• ywnJ

Important publications on the SigM regulon

John D Helmann
Bacillus subtilis extracytoplasmic function (ECF) sigma factors and defense of the cell envelope.
Curr Opin Microbiol: 2016, 30;122-132
[PubMed:26901131] [WorldCat.org] [DOI] (I p)

Satoshi Matsuoka, Minako Chiba, Yu Tanimura, Michihiro Hashimoto, Hiroshi Hara, Kouji Matsumoto
Abnormal morphology of Bacillus subtilis ugtP mutant cells lacking glucolipids.
Genes Genet Syst: 2011, 86(5);295-304
[PubMed:22362028] [WorldCat.org] [DOI] (I p)

Tina Wecke, Tobias Bauer, Henning Harth, Ulrike Mäder, Thorsten Mascher
The rhamnolipid stress response of Bacillus subtilis.
FEMS Microbiol Lett: 2011, 323(2);113-23
[PubMed:22092710] [WorldCat.org] [DOI] (I p)

Warawan Eiamphungporn, John D Helmann
The Bacillus subtilis sigma(M) regulon and its contribution to cell envelope stress responses.
Mol Microbiol: 2008, 67(4);830-48
[PubMed:18179421] [WorldCat.org] [DOI] (P p)

Thorsten Mascher, Anna-Barbara Hachmann, John D Helmann
Regulatory overlap and functional redundancy among Bacillus subtilis extracytoplasmic function sigma factors.
J Bacteriol: 2007, 189(19);6919-27
[PubMed:17675383] [WorldCat.org] [DOI] (P p)

Adrian J Jervis, Penny D Thackray, Chris W Houston, Malcolm J Horsburgh, Anne Moir
SigM-responsive genes of Bacillus subtilis and their promoters.
J Bacteriol: 2007, 189(12);4534-8
[PubMed:17434969] [WorldCat.org] [DOI] (P p)