NadD

• Description: nicotinamide-nucleotide adenylyltransferase
  
  

Gene name	nadD
Synonyms	yqeJ
Essential	yes PubMed
Product	nicotinamide-nucleotide adenylyltransferase
Function	NAD biosynthesis
Gene expression levels in SubtiExpress: nadD
Metabolic function and regulation of this protein in SubtiPathways: NadD
MW, pI	22 kDa, 5.123
Gene length, protein length	567 bp, 189 aa
Immediate neighbours	yqeK, yqeI
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

biosynthesis of cofactors, essential genes

The gene

Basic information

• Locus tag: BSU25640

Phenotypes of a mutant

essential PubMed

Database entries

• BsubCyc: BSU25640

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD⁺ (according to Swiss-Prot)

• Protein family: nadD family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• BsubCyc: BSU25640

• Structure: 1KAQ

• UniProt: P54455

• KEGG entry: [2]

• E.C. number: 2.7.7.18

Expression and regulation

• Operon:

• Expression browser: nadD PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Andrea M Olland, Kathryn W Underwood, Robert M Czerwinski, Mei-Chu Lo, Ann Aulabaugh, Joel Bard, Mark L Stahl, William S Somers, Francis X Sullivan, Rajiv Chopra
Identification, characterization, and crystal structure of Bacillus subtilis nicotinic acid mononucleotide adenylyltransferase.
J Biol Chem: 2002, 277(5);3698-707
[PubMed:11704676] [WorldCat.org] [DOI] (P p)