PhrC

• Description: phosphatase (RapC) regulator / competence and sporulation stimulating factor (CSF)
  
  

Gene name	phrC
Synonyms
Essential	no
Product	phosphatase (RapC) regulator / competence and sporulation stimulating factor (CSF)
Function	control of sporulation initiation
MW, pI	4 kDa, 8.16
Gene length, protein length	120 bp, 40 aa
Immediate neighbours	rapC, yclM
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU03780

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: phr family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions: RapC-PhrC

• Localization:

Database entries

• Structure:

• Swiss prot entry: P94416

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon:

• Sigma factor:

• Regulation: repressed by glucose (4.5-fold) (CcpA) PubMed
  • repressed during growth in the presence of branched chain amino acids (CodY) PubMed

• Regulatory mechanism: CcpA: transcription repression
  • CodY: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Hans-Matti Blencke, Georg Homuth, Holger Ludwig, Ulrike Mäder, Michael Hecker, Jörg Stülke
Transcriptional profiling of gene expression in response to glucose in Bacillus subtilis: regulation of the central metabolic pathways.
Metab Eng: 2003, 5(2);133-49
[PubMed:12850135] [WorldCat.org] [DOI] (P p)

B A Lazazzera, I G Kurtser, R S McQuade, A D Grossman
An autoregulatory circuit affecting peptide signaling in Bacillus subtilis.
J Bacteriol: 1999, 181(17);5193-200
[PubMed:10464187] [WorldCat.org] [DOI] (P p)

1. Blencke et al. (2003) Transcriptional profiling of gene expression in response to glucose in Bacillus subtilis: regulation of the central metabolic pathways. Metab Eng. 5: 133-149 PubMed
2. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed