Zwf

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  • Description: glucose 6-phosphate dehydrogenase, pentose-phosphate pathway

Gene name zwf
Synonyms yqjJ
Essential no
Product glucose 6-phosphate dehydrogenase
Function initiation of the pentose phosphate pathway
MW, pI 55 kDa, 5.28
Gene length, protein length 1467 bp, 489 aa
Immediate neighbours rnz, gndA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
Zwf context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU23850

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH (according to Swiss-Prot)
  • Protein family: glucose-6-phosphate dehydrogenase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information: Two Substrate Michaelis-Menten PubMed
  • Domains:
  • Modification:
  • Cofactor(s): Mg2+, Mn2+, Ca2+
  • Effectors of protein activity:
    • NAD+, NADP+ and NADPH affect the enzyme kinetic PubMed
  • Interactions:
  • Localization:

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

The enzyme is a dimer PubMed

Expression and regulation

  • Regulation: constitutive PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

  1. Blencke, H.-M., Homuth, G., Ludwig, H., Mäder, U., Hecker, M. & Stülke, J. (2003) Transcriptional profiling of gene expression in response to glucose in Bacillus subtilis: regulation of the central metabolic pathways. Metab. Engn. 5: 133-149. PubMed
  2. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed