SucC

• Description: succinyl-CoA synthetase (beta subunit)
  
  

Gene name	sucC
Synonyms
Essential	no
Product	succinyl-CoA synthetase (beta subunit)
Function	TCA cycle
MW, pI	41 kDa, 4.846
Gene length, protein length	1155 bp, 385 aa
Immediate neighbours	ylqH, sucD
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Coordinates:

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: ATP + succinate + CoA = ADP + phosphate + succinyl-CoA (according to Swiss-Prot)

• Protein family: ATP-grasp domain (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylation on Ser-220 PubMed

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 1JKJ (E. coli)

• Swiss prot entry: P80886

• KEGG entry: BSU16090

• E.C. number: 6.2.1.5

Expression and regulation

• Operon: sucC-SucD

• Sigma factor:

• Regulation: repressed by glucose (2.7-fold) (CcpA) PubMed

• Regulatory mechanism: CcpA: transcription repression

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

1. Blencke et al. (2003) Transcriptional profiling of gene expression in response to glucose in Bacillus subtilis: regulation of the central metabolic pathways. Metab Eng. 5: 133-149 PubMed# Macek et al. (2007) The serine/ threonine/ tyrosine phosphoproteome of the model bacterium Bacillus subtilis. Mol. Cell. Proteomics 6: 697-707 PubMed
2. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed