pabA

pabA
168

para-aminobenzoate synthase (subunit B)/ anthranilate synthase (subunit II), glutaminase subunit

Locus
BSU_00750
Molecular weight
21.54 kDa
Isoelectric point
4.78
Protein length
194 aaSequenceBlast
Gene length
585 bpSequenceBlast
Function
biosynthesis of folate and tryptophan
Product
para-aminobenzoate synthase (subunit B)/ anthranilate synthase (subunit II) glutamine amidotransferase (subunit B) and anthranilate synthase (subunit II)
Essential
no
E.C.
2.6.1.85
Synonyms
pabA, trpG, trpX
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0512 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
84,290  84,874
The protein
Catalyzed reaction/ biological activity
chorismate + L-glutamine --> anthranilate + pyruvate + L-glutamate (according to UniProt)
Domains
Glutamine amidotransferase type-1 domain (aa 1-194) (according to UniProt)
Structure
6QUR (PDB) (synthetic construct, 72.9% identity) PubMed
1I1Q (PDB) (from Salmonella typhimurium, 42% identity) PubMed
P28819 (AlphaFold)
Expression and Regulation
Operons
Genes
pabB-pabA-pabC-sul-folB-folK-yazB-dusB1-lysS
Description
PubMed
Regulation
translation repressed by tryptophan (MtrB) PubMed
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
Open in new tab

pabB→lysS

2025-03-09 09:09:51

Jstuelk

120

8c465dd3eec1aaa32d5e91206834f9bb99ef474a

7B9041CE94396BF42D285F7C0EDD3A2544761EEE

Other regulations
MtrB: translation inhibition, PubMed
Additional information
the pabA-pabC part of the mRNA is substantially stabilized upon depletion of RNase Y PubMed
Biological materials
Mutant
BKE00750 (pabA::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTAAAATCATTTCTCCGC,  downstream forward: _UP4_TATCGCAAGGAAGTTATTGC
BKK00750 (pabA::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTAAAATCATTTCTCCGC,  downstream forward: _UP4_TATCGCAAGGAAGTTATTGC
References
Reviews
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Original Publications
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956E33AAAADB302EB8663E4B75C917242D3AD2C0

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Time of last update: 2025-04-03 00:51:03

Author of last update: Jstuelk