LutA

• Description: lactate catabolic enzyme
  
  

Gene name	lutA
Synonyms	yvfV
Essential	no
Product	lactate oxidase
Function	lactate utilization
MW, pI	26 kDa, 6.25
Gene length, protein length	714 bp, 238 aa
Immediate neighbours	lutB, yvfU
Gene sequence (+200bp)	Protein sequence
Genetic context

The gene

Basic information

• Coordinates:

Phenotypes of a mutant

no growth with lactate as the single carbon source PubMed

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: oxidation of lactate to pyruvate PubMed

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• Swiss prot entry:

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: lutA-lutB-lutC PubMed

• Sigma factor:

• Regulation: induction by lactate PubMed

• Regulatory mechanism: dual repression by LutR (inducer lactate) and SinR PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Richard Losick, Harvard Univ., Cambridge, USA homepage

References

1. Chai Y, Kolter R, Losick R. (2009) A WIDELY CONSERVED GENE CLUSTER REQUIRED FOR LACTATE UTILIZATION IN BACILLUS SUBTILIS AND ITS INVOLVEMENT IN BIOFILM FORMATION. J Bacteriol. Feb 6. Epub ahead of print PubMed
2. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed