KtrC
Gene name | ktrC |
Synonyms | ylxV, yzaC, ykqB |
Essential | no |
Product | low affinity potassium transporter KtrC-KtrD, peripheric membrane component (proton symport) |
Function | potassium uptake |
Gene expression levels in SubtiExpress: ktrC | |
Interactions involving this protein in SubtInteract: KtrC | |
Metabolic function and regulation of this protein in SubtiPathways: Metal ion homeostasis, ktrC | |
MW, pI | 24 kDa, 5.63 |
Gene length, protein length | 663 bp, 221 aa |
Immediate neighbours | ykqA, adeC |
Sequences | Protein DNA DNA_with_flanks |
Genetic context This image was kindly provided by SubtiList
| |
Expression at a glance PubMed |
Contents
Categories containing this gene/protein
transporters/ other, metal ion homeostasis (K, Na, Ca, Mg), coping with hyper-osmotic stress, membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU14510
Phenotypes of a mutant
Database entries
- BsubCyc: BSU14510
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s): KtrA
Extended information on the protein
- Kinetic information:
- Domains:
- contains a RCK_N domain at the N-terminus (according to UniProt, [2])
- contains a c-di-AMP-binding RCK_C domain at the C-terminus (according to UniProt, [3]) PubMed
- Modification:
- Effectors of protein activity:
- the protein binds c-di-AMP PubMed
- Localization: peripheral membrane protein PubMed
Database entries
- BsubCyc: BSU14510
- Structure:
- UniProt: P39760
- KEGG entry: [4]
- E.C. number:
Additional information
Expression and regulation
- Operon: ktrC PubMed
- Sigma factor:
- Regulation: constitutively expressed PubMed
- Regulatory mechanism:
- Additional information:
- number of protein molecules per cell (minimal medium with glucose and ammonium, exponential phase): 576 PubMed
- number of protein molecules per cell (minimal medium with glucose and ammonium, early stationary phase after glucose exhaustion): 453 PubMed
- number of protein molecules per cell (minimal medium with glucose and ammonium, late stationary phase after glucose exhaustion): 601 PubMed
Biological materials
- Mutant:
- GHB6 (ktrC::spec), PubMed (available in Erhard Bremer's and Jörg Stülke's) labs, available at BGSC as 1A955
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Erhard Bremer, University of Marburg, Germany homepage
Your additional remarks
References
Reviews
Fabian M Commichau, Achim Dickmanns, Jan Gundlach, Ralf Ficner, Jörg Stülke
A jack of all trades: the multiple roles of the unique essential second messenger cyclic di-AMP.
Mol Microbiol: 2015, 97(2);189-204
[PubMed:25869574]
[WorldCat.org]
[DOI]
(I p)
Original publications
Rebecca M Corrigan, Ivan Campeotto, Tharshika Jeganathan, Kevin G Roelofs, Vincent T Lee, Angelika Gründling
Systematic identification of conserved bacterial c-di-AMP receptor proteins.
Proc Natl Acad Sci U S A: 2013, 110(22);9084-9
[PubMed:23671116]
[WorldCat.org]
[DOI]
(I p)
Gudrun Holtmann, Evert P Bakker, Nobuyuki Uozumi, Erhard Bremer
KtrAB and KtrCD: two K+ uptake systems in Bacillus subtilis and their role in adaptation to hypertonicity.
J Bacteriol: 2003, 185(4);1289-98
[PubMed:12562800]
[WorldCat.org]
[DOI]
(P p)