Prp

• Description: protein cysteine protease, required for N-terminal cleavage of ribosomal protein L27
  
  

Gene name	prp
Synonyms	ysxB
Essential	no
Product	L27 protein cysteine protease
Function	maturation of L27
Gene expression levels in SubtiExpress: prp
MW, pI	12 kDa, 4.456
Gene length, protein length	336 bp, 112 aa
Immediate neighbours	rpmA, rplU
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

translation, proteolysis

This gene is a member of the following regulons

stringent response

The gene

Basic information

• Locus tag: BSU27950

Database entries

• BsubCyc: BSU27950

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:
  • N-terminal cleavage of ribosomal protein L27 PubMed

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactors:

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• BsubCyc: BSU27950

• Structure: 2P92 (the protein from S. aureus)

• UniProt: P26942

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: ysxB PubMed

• Sigma factor:

• Regulation:
  • RelA dependent downregulation (Class I) during stringent response PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Erin A Wall, J Harry Caufield, Charles E Lyons, Keith A Manning, Terje Dokland, Gail E Christie
Specific N-terminal cleavage of ribosomal protein L27 in Staphylococcus aureus and related bacteria.
Mol Microbiol: 2015, 95(2);258-69
[PubMed:25388641] [WorldCat.org] [DOI] (I p)

Christine Eymann, Georg Homuth, Christian Scharf, Michael Hecker
Bacillus subtilis functional genomics: global characterization of the stringent response by proteome and transcriptome analysis.
J Bacteriol: 2002, 184(9);2500-20
[PubMed:11948165] [WorldCat.org] [DOI] (P p)