PsdR

• Description: two-component response regulator (OmpR family), induction of psdA-psdB in response to lipid II-binding lantibiotics, such as nisin and gallidermin
  
  

Gene name	psdR
Synonyms	yvcP
Essential	no
Product	two-component response regulator (OmpR family)
Function	resistance against toxic peptides
Gene expression levels in SubtiExpress: psdR
Interactions involving this protein in SubtInteract: PsdR
MW, pI	27 kDa, 4.676
Gene length, protein length	711 bp, 237 aa
Immediate neighbours	psdS, yvzJ
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transcription factors and their control, resistance against toxins/ antibiotics, phosphoproteins

The gene

Basic information

• Locus tag: BSU34720

Database entries

• BsubCyc: BSU34720

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: OmpR family of two-component response regulators

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylated by PsdS on an Asp residue

• Cofactor(s):

• Effectors of protein activity: phosphorylation likely affects DNA-binding activity

• Interactions:
  • PsdR-PsdS

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• BsubCyc: BSU34720

• Structure:

• UniProt: O06978

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: psdR-psdS-psdA-psdB PubMed

• Expression browser: psdR PubMed

• Sigma factor: SigA PubMed

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Additional publications: PubMed

Stéphanie Coumes-Florens, Céline Brochier-Armanet, Annick Guiseppi, François Denizot, Maryline Foglino
A new highly conserved antibiotic sensing/resistance pathway in firmicutes involves an ABC transporter interplaying with a signal transduction system.
PLoS One: 2011, 6(1);e15951
[PubMed:21283517] [WorldCat.org] [DOI] (I e)

Eva Rietkötter, Diana Hoyer, Thorsten Mascher
Bacitracin sensing in Bacillus subtilis.
Mol Microbiol: 2008, 68(3);768-85
[PubMed:18394148] [WorldCat.org] [DOI] (I p)

Thorsten Mascher, Neil G Margulis, Tao Wang, Rick W Ye, John D Helmann
Cell wall stress responses in Bacillus subtilis: the regulatory network of the bacitracin stimulon.
Mol Microbiol: 2003, 50(5);1591-604
[PubMed:14651641] [WorldCat.org] [DOI] (P p)

C Fabret, V A Feher, J A Hoch
Two-component signal transduction in Bacillus subtilis: how one organism sees its world.
J Bacteriol: 1999, 181(7);1975-83
[PubMed:10094672] [WorldCat.org] [DOI] (P p)