KipI

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Gene name kipI
Synonyms ycsJ
Essential no
Product inhibitor of KinA
Function control of the phosphorelay, initiation of sporulation
Gene expression levels in SubtiExpress: kipI
Interactions involving this protein in SubtInteract: KipI
Function and regulation of this protein in SubtiPathways:
kipI
MW, pI 26 kDa, 4.656
Gene length, protein length 720 bp, 240 aa
Immediate neighbours ycsI, kipA
Sequences Protein DNA DNA_with_flanks
Genetic context
KipI context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
KipI expression.png




























Categories containing this gene/protein

phosphorelay

This gene is a member of the following regulons

KipR regulon, TnrA regulon

The gene

Basic information

  • Locus tag: BSU04080

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):

Database entries

  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation:
  • Additional information:
    • number of protein molecules per cell (minimal medium with glucose and ammonium, exponential phase): 817 PubMed
    • number of protein molecules per cell (minimal medium with glucose and ammonium, early stationary phase after glucose exhaustion): 405 PubMed
    • number of protein molecules per cell (minimal medium with glucose and ammonium, late stationary phase after glucose exhaustion): 670 PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

David A Jacques, David B Langley, Robert M G Hynson, Andrew E Whitten, Ann Kwan, J Mitchell Guss, Jill Trewhella
A novel structure of an antikinase and its inhibitor.
J Mol Biol: 2011, 405(1);214-26
[PubMed:21050859] [WorldCat.org] [DOI] (I p)

Robert M G Hynson, Ann H Kwan, David A Jacques, Joel P Mackay, Jill Trewhella
1H, 13C and 15N backbone and side chain resonance assignments of the N-terminal domain of the histidine kinase inhibitor KipI from Bacillus subtilis.
Biomol NMR Assign: 2010, 4(2);167-9
[PubMed:20524093] [WorldCat.org] [DOI] (I p)

David A Jacques, David B Langley, Cy M Jeffries, Katherine A Cunningham, William F Burkholder, J Mitchell Guss, Jill Trewhella
Histidine kinase regulation by a cyclophilin-like inhibitor.
J Mol Biol: 2008, 384(2);422-35
[PubMed:18823995] [WorldCat.org] [DOI] (I p)

L Wang, R Grau, M Perego, J A Hoch
A novel histidine kinase inhibitor regulating development in Bacillus subtilis.
Genes Dev: 1997, 11(19);2569-79
[PubMed:9334321] [WorldCat.org] [DOI] (P p)