YwpB

• Description: β-hydroxyacyl-(acyl carrier protein) dehydratase
  
  

Gene name	ywpB
Synonyms	fabZ
Essential	yes PubMed
Product	β-hydroxyacyl-ACP dehydratase
Function	fatty acid biosynthesis
Gene expression levels in SubtiExpress: ywpB
Metabolic function and regulation of this protein in SubtiPathways: ywpB
MW, pI	14 kDa, 9.36
Gene length, protein length	396 bp, 132 aa
Immediate neighbours	mscL, rapD
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

biosynthesis of lipids, essential genes

The gene

Basic information

• Locus tag: BSU36370

Phenotypes of a mutant

• essential PubMed

Database entries

• BsubCyc: BSU36370

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: FabZ subfamily (according to Swiss-Prot)

• Paralogous protein(s): YcsD

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• BsubCyc: BSU36370

• Structure: 3D6X (from Campylobacter jejuni, 45% identity, 67% similarity) PubMed

• UniProt: P94584

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: ywpB PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:
  • number of protein molecules per cell (minimal medium with glucose and ammonium): 138 PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Additional publications: PubMed

Andrew S Kirkpatrick, Takeshi Yokoyama, Kyoung-Jae Choi, Hye-Jeong Yeo
Campylobacter jejuni fatty acid synthase II: structural and functional analysis of beta-hydroxyacyl-ACP dehydratase (FabZ).
Biochem Biophys Res Commun: 2009, 380(2);407-12
[PubMed:19280690] [WorldCat.org] [DOI] (I p)

Yasutaro Fujita, Hiroshi Matsuoka, Kazutake Hirooka
Regulation of fatty acid metabolism in bacteria.
Mol Microbiol: 2007, 66(4);829-39
[PubMed:17919287] [WorldCat.org] [DOI] (P p)