GtaB

• Description: UTP-glucose-1-phosphate uridylyltransferase, general stress protein
  
  

Gene name	gtaB
Synonyms
Essential	no
Product	UTP-glucose-1-phosphate uridylyltransferase
Function	biosynthesis of teichoic acid
Gene expression levels in SubtiExpress: gtaB
Metabolic function and regulation of this protein in SubtiPathways: gtaB
MW, pI	32 kDa, 4.913
Gene length, protein length	876 bp, 292 aa
Immediate neighbours	mnaA, yvzH
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

cell wall synthesis, lipid metabolism/ other, biosynthesis of cell wall components, general stress proteins (controlled by SigB), phosphoproteins

This gene is a member of the following regulons

SigB regulon

The gene

Basic information

• Locus tag: BSU35670

Phenotypes of a mutant

• the inactivation of gtaB suppresses the poor and filametous growth of the yvcL zapA double mutant PubMed

Database entries

• BsubCyc: BSU35670

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose (according to Swiss-Prot)

• Protein family: UDPGP type 2 family (according to Swiss-Prot)

• Paralogous protein(s): YngB, YtdA

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:
  • phosphorylated on Arg-76 PubMed
  • phosphorylated on ser/ thr/ tyr PubMed

• Cofactors:

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• BsubCyc: BSU35670

• Structure: 2E3D (from E. coli, 44% identity, 61% similarity) PubMed

• UniProt: Q05852

• KEGG entry: [3]

• E.C. number: 2.7.7.9

Expression and regulation

• Operon: gtaB PubMed

• Expression browser: gtaB PubMed

• Sigma factor: SigA PubMed, SigB PubMed

• Regulation:
  • induced by stress (SigB) PubMed

• Regulatory mechanism:

• Additional information:
  • number of protein molecules per cell (minimal medium with glucose and ammonium): 3693 PubMed
  • number of protein molecules per cell (complex medium with amino acids, without glucose): 8998 PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: