YfkM

• Description: glyoxalase III-like enzyme, general stress protein, survival of salt, paraquat and ethanol stresses
  
  

Gene name	yfkM
Synonyms
Essential	no
Product	glyoxalase III-like enzyme
Function	detoxification of methylglyoxal
Gene expression levels in SubtiExpress: yfkM
Metabolic function and regulation of this protein in SubtiPathways: YfkM
MW, pI	18 kDa, 4.722
Gene length, protein length	516 bp, 172 aa
Immediate neighbours	yfkN, yfkL
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

general stress proteins (controlled by SigB), resistance against oxidative and electrophile stress

This gene is a member of the following regulons

Fur regulon, SigB regulon

The gene

Basic information

• Locus tag: BSU07850

Database entries

• BsubCyc: BSU07850

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:
  • methylglyoxal --> D-lactate PubMed

• Protein family: PfpI endopeptidase domain (according to Swiss-Prot)

• Paralogous protein(s): YraA

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactors:

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• BsubCyc: BSU07850

• Structure:

• UniProt: P80876

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: yfkM PubMed

• Expression browser: yfkM PubMed

• Sigma factor: SigB PubMed

• Regulation:
  • induced by stress (SigB) PubMed
  • induced upon iron starvation (Fur) PubMed

• Regulatory mechanism:
  • Fur: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: