YraA

• Description: general stress protein, degradation of damaged thiol-containing proteins, glyoxalase III-like enzyme
  
  

Gene name	yraA
Synonyms
Essential	no
Product	glyoxalase III-like enzyme
Function	detoxification of methylglyoxal
Gene expression levels in SubtiExpress: yraA
Metabolic function and regulation of this protein in SubtiPathways: YraA
MW, pI	18 kDa, 4.729
Gene length, protein length	507 bp, 169 aa
Immediate neighbours	adhA, sacC
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed 500px

Categories containing this gene/protein

proteolysis, general stress proteins (controlled by SigB), resistance against oxidative and electrophile stress

This gene is a member of the following regulons

AdhR regulon, SigB regulon, SigM regulon

The gene

Basic information

• Locus tag: BSU27020

Database entries

• BsubCyc: BSU27020

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:
  • methylglyoxal --> D-lactate PubMed

• Protein family: peptidase C56 family (according to Swiss-Prot)

• Paralogous protein(s): YfkM

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactors:

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• BsubCyc: BSU27020

• Structure:

• UniProt: O06006

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon:
  • adhA-yraA PubMed
  • yraA

• Expression browser: yraA PubMed

• Sigma factor:
  • yraA: SigB PubMed, SigM PubMed

• Regulation:
  • adhA: induced in the presence of the toxic carbonyls methylglyoxal and formaldehyde (AdhR) PubMed
  • yraA: induced by stress (SigB) PubMed

• Regulatory mechanism:
  • AdhR: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: